Vitamin D (Calcitriol)
Vitamin D is a fat-soluble vitamin. It occurs naturally in a few foods. However, the quantity is not sufficient. Hence, numerous dietary supplements of Vitamin D can be found being sold in drug stores. It is also produced within the body when UV rays from the sun trigger the synthesis of this vitamin upon coming in contact with the skin.
Calcitriol is an active form of this vitamin. It is offered by the manufacturers either as capsules or as injections. The wholesale cost of this drug is about £22.
Why is Vitamin D (Calcitriol) prescribed?
Calcitriol is generally prescribed to patients who have low calcium levels in their bodies. It is beneficial in treating bone diseases in patients whose parathyroid glands or kidneys are not functioning in a normal way.
Calcitriol is also used in treating secondary hyperparathyroidism. This condition results in excess production of parathyroid hormone which is responsible for maintaining the level of calcium in the blood. It is also beneficial in the case of metabolic bone disease. This drug belongs to a group of medications referred to as Vitamin D analogs. It functions by assisting the body to utilize more of calcium found in supplements or foods.
Calcitriol is also prescribed sometimes for the treatment of rickets, familial hypophosphatemia, and osteomalacia. It is also used for increasing the amount of calcium in premature babies.
How should Calcitriol be taken?
Calcitriol is offered by the manufacturers in the form of a solution or a capsule. These are taken orally once a day. The instructions given by the doctor have to be followed. Also, one can check the manufacturers’ labels for the dosage. The doctors usually recommend a small dosage and then gradually increase it based on the condition of the patient being treated.
Mechanism of action of Calcitriol
Calcitriol primarily increases the level of calcium in the blood. It
Promotes absorption of dietary calcium
Increases the renal tubular reabsorption of calcium thereby reducing the loss of calcium in the urine
Stimulates the release of calcium from bone
Synthesis and regulation of Calcitriol
Calcitriol is produced primarily in the proximal tubule of the nephron in the kidneys. This is due to the action of various enzymes. The production of calcitriol is further increased by prolactin which is a hormone. It stimulates lactogenesis which is a process necessary for producing a large amount of calcium in the body. It is also produced outside the kidney but in small quantities.
Calcitriol was first identified by Michael F Holick in 1971. He was working in the laboratory of Hector DeLuca. Tony Normal and his colleagues also contributed significantly to the development and synthesis of this calcitriol.
Connect with leading Calcitriol manufacturers and Calcitriol manufacturers
Distributors can connect with the leading Calcitriol suppliers by registering on Pipelinepharma. This platform is a leading online pharma marketplace. Only verified manufacturers can post a listing over this platform.
The distributors are provided with a lot of convenient options in shortlisting Calcitriol suppliers of their choice. You can find a manufacturer based on the region, dossier status, wholesale cost, and GMP approvals. This will help you make the right decision for your company.