Generics 104

Originals

Biosimilars

Medical devices

Nutraceuticals

Filters

Methotrexate manufacturers

104 products found

Filters

104 products found

methotrexate

Solution for injection/infusion 100mg/ml

Dossier type
EU CTD
Dossier status
Ready to file
Country of origin
Switzerland
GMP approvals
EU GMP
Unavailable markets
United Kingdom , Germany , Vietnam
Available for
Distribution only
Manufacturer #269
A pharmaceutical manufacturer based in the EU that is active in 100+ countries selling its products in Europe, North America, Africa, the Middle East, and Asia for 40+ years. Main therapeutic areas include CNS, cardiovascular medication, and anti-infectives. The company's production lines are EU GMP-compliant. Key production lines are Rx and OTC. The company owns 20+ branches in Europe, Africa, and Asia.

Manufacturer usually replies in 5 days

methotrexate

Oral solution 2mg/ml

Dossier type
EU CTD
Dossier status
Ready to file
Country of origin
European Union
GMP approvals
EU GMP
Registered in
United Kingdom
Available for
Distribution only
Manufacturer #12183
An international pharmaceutical company that is known to provide innovative solutions with the objective of patient care at its heart. A specially enabled pharmaceutical company that also focuses on marketization and commercialization of products at the same time.

Manufacturer usually replies in 8 days

methotrexate

Tablets, film coated 2.5 mg

Dossier type
EU CTD
Dossier status
Ready to file
Country of origin
European Union
GMP approvals
EU GMP
Unavailable markets
Vietnam
Manufacturer #519

Manufacturer usually replies in 6 days

methotrexate

Injection, pre-filled syringe 5 mg, 7.5 mg, 10 mg, 12.5 mg, 15 mg, 17.5 mg, 20 mg, 22.5 mg, 25 mg, 27.5 mg, 30 mg

Dossier type
EU CTD
Dossier status
Ready to file
Country of origin
European Union
GMP approvals
EU GMP
Unavailable markets
Greece
Manufacturer #5738
A pharmaceutical manufacturer based in the EU that has been active in the development, licensing, registration, manufacturing, and commercialization for 20+ years. Key production lines are Rx, OTC, and medical devices. The company's production lines are GMP-compliant. Main dosage forms include liquids and semi-solids.

Manufacturer usually replies in 9 days

methotrexate

Solution for injection 2.5 mg/ml, 25 mg/ml

Dossier type
EU CTD
Dossier status
Ready to file
Country of origin
European Union
GMP approvals
EU GMP
Registered in
Germany
Available for
Licensing with supply, Distribution only
Manufacturer #16717
They've been serving and assisting customers in the healthcare business in Regulatory Affairs and Pharmacovigilance for over 30 years. This sphere of action covers many countries around the world. They look after their local and European consumers and the supply chain by providing high-quality products for internationalization strategies.

Manufacturer usually replies in 14 days

methotrexate

Oral solution 2 mg/5 ml

Dossier type
EU CTD
Dossier status
Ready to file
Country of origin
European Union
GMP approvals
EU GMP
Manufacturer #21467

Manufacturer usually replies in 7 days

methotrexate

Solution for injection 50 mg/ml

Dossier type
EU CTD
Dossier status
Under development
Country of origin
European Union
GMP approvals
EU GMP
Comments
RLD-Metex (Medac) Dossier availability date: Q3 2026
Manufacturer #19992
A pharmaceutical manufacturer based in the EU that is active in 20+ countries selling its products for 190+ years. Key production lines are Rx, OTC, medical devices, and nutraceuticals. The company's production lines are GMP-compliant. Main therapy areas include anti-infectives, dermatology, and CNS. The company products are prepared in CTD dossier format.

Manufacturer usually replies in 6 days

methotrexate

Injection, pre-filled syringe 7,5mg/0,3ml, 10mg/0,4ml, 15mg/0,6ml, 20mg/0,8ml, 25mg/1ml

Dossier type
EU CTD
Dossier status
Ready to file
Country of origin
Canada
GMP approvals
EU GMP
Manufacturer #7167
A pharmaceutical manufacturer based in the EU that has been active in 40+ countries for 50+ years. Key production lines are Rx and nutraceuticals. The main therapeutic areas include musculoskeletal, respiratory, and dermatology. The company possesses subsidiaries in LATAM.

Manufacturer usually replies in 6 days

methotrexate

Tablets 2,5mg, 10mg

Dossier type
EU CTD
Dossier status
Ready to file
Country of origin
European Union
GMP approvals
EU GMP
Manufacturer #1179

methotrexate

Solution for injection/infusion 25 mg/ml

Dossier type
EU CTD
Dossier status
Ready to file
Country of origin
Canada
GMP approvals
EU GMP, Canada
Comments
Reference product : Metoject (Medexus)
Manufacturer #278

The company has become a prominent partner of the pharmacy community in North America, with the fastest rising market share among generic leaders. It can provide best-in-class supply reliability thanks to production capacity. In more than 50 countries, it's available locally or through corporate partnerships. R&D expenditures range from $40 million to $50 million per year. They are dedicated to maintaining a customer satisfaction rate of over 95% by continuously enhancing supply chain efficiency.

Manufacturer usually replies in 7 days

methotrexate

injectable solution, pre-filled syringe 7.5, 10, 12.5, 15, 17.5, 20, 22.5, 25, 27.5 and 30 mg

Dossier type
EU CTD
Dossier status
Ready to file
Country of origin
European Union
GMP approvals
EU GMP
Manufacturer #535

Manufacturer usually replies in nan days

methotrexate

Injection 500 mg

Dossier type
CTD
Dossier status
Ready to file
Country of origin
Pakistan
GMP approvals
FDA
Manufacturer #20861

Manufacturer usually replies in 4 days

methotrexate

Injection, pre-filled syringe 50 mg/ml - 0.2 ml, 0.25 ml, 0.3 ml, 0.35 ml, 0.4 ml, 0.45 ml, 0.5 mL

Dossier type
CTD
Dossier status
Under development
Country of origin
Canada
GMP approvals
Canada
Comments
Reference product : Rasuvo (Medexus Pharma)
Manufacturer #278

The company has become a prominent partner of the pharmacy community in North America, with the fastest rising market share among generic leaders. It can provide best-in-class supply reliability thanks to production capacity. In more than 50 countries, it's available locally or through corporate partnerships. R&D expenditures range from $40 million to $50 million per year. They are dedicated to maintaining a customer satisfaction rate of over 95% by continuously enhancing supply chain efficiency.

Manufacturer usually replies in 7 days

methotrexate

Injection, pre-filled syringe 50 mg/ml - 0.2 ml, 0.25 ml, 0.3 ml, 0.35 ml, 0.4 ml, 0.45 ml, 0.5 ml

Dossier type
CTD
Dossier status
Under development
Country of origin
Canada
GMP approvals
Canada
Comments
Rasuvo (Medexus Pharma)
Manufacturer #278

The company has become a prominent partner of the pharmacy community in North America, with the fastest rising market share among generic leaders. It can provide best-in-class supply reliability thanks to production capacity. In more than 50 countries, it's available locally or through corporate partnerships. R&D expenditures range from $40 million to $50 million per year. They are dedicated to maintaining a customer satisfaction rate of over 95% by continuously enhancing supply chain efficiency.

Manufacturer usually replies in 7 days

methotrexate

Vials 50 mg/2 ml, 500 mg/20 ml, 1000 mg/40 ml, 5000 mg/50 ml

Dossier type
CTD
Dossier status
Ready to file
Country of origin
Turkey
GMP approvals
EU GMP
Manufacturer #2722
It originally entered the pharmaceutical industry in 1987, when it introduced blood derivative products to Europe and became the exclusive distributor for prominent European brands. Oncology, hematology, dermatology, radiology, rheumatology, immunology, and OTC products are the seven main therapeutic fields.

Manufacturer usually replies in 6 days

methotrexate

Injection, pre-filled syringe 10 mg/0.4 ml, 15 mg/0.6 ml, 20 mg/0.8 ml, 25 mg/ml, 7.5 mg/0.3 ml, 12.5 mg/0.5 ml, 17.5 mg/0.7 ml, 22.5 mg/0.9 ml

Dossier type
CTD
Dossier status
Ready to file
Country of origin
Turkey
GMP approvals
EU GMP
Unavailable markets
Colombia
Manufacturer #2722
It originally entered the pharmaceutical industry in 1987, when it introduced blood derivative products to Europe and became the exclusive distributor for prominent European brands. Oncology, hematology, dermatology, radiology, rheumatology, immunology, and OTC products are the seven main therapeutic fields.

Manufacturer usually replies in 6 days

methotrexate

Tablets 2.5 mg , 5 mg , 10 mg

Dossier type
CTD
Dossier status
Ready to file
Country of origin
India
GMP approvals
WHO
Manufacturer #22283

Manufacturer usually replies in 4 days

methotrexate

Injection 1 g , 50 mg , 500 mg

Dossier type
CTD
Dossier status
Ready to file
Country of origin
India
GMP approvals
WHO
Manufacturer #22283

Manufacturer usually replies in 4 days

methotrexate

Solution for infusion 50 mg

Dossier type
CTD
Dossier status
Ready to file
Country of origin
India
GMP approvals
PICS
Manufacturer #21567

Manufacturer usually replies in 2 days

methotrexate

Injection 50 mg

Dossier type
CTD
Dossier status
Ready to file
Country of origin
Pakistan
GMP approvals
Sri Lanka, Afghanistan, Vietnam, Cambodia, Myanmar
Manufacturer #21102

Manufacturer usually replies in 5 days

Want to view all 104 products? Create your free account today!

Methotrexate manufacturers

What is Methotrexate?

Methotrexate is a medication used to treat various medical conditions, including cancer, autoimmune diseases, and certain types of arthritis. It is classified as an antimetabolite and works by interfering with the growth and replication of rapidly dividing cells, such as cancer and immune cells.

In cancer treatment, Methotrexate is often used to treat certain types of leukaemia, lymphoma, and other solid tumours. It is also used to treat non-cancerous conditions, such as psoriasis and rheumatoid arthritis, by suppressing the activity of the immune system.

Methotrexate is typically taken in tablet form or injected into a muscle or vein. Treatment dosage and duration will depend on the individual's medical condition and other factors and should only be determined by a healthcare provider.

Methotrexate can cause side effects depending on the individual and the dosage used. Common side effects of Methotrexate include vomiting, nausea, fatigue and hair loss. Methotrexate can also cause more severe side effects, such as liver damage and a decrease in blood cells amount in the body, which can increase the risk of infection or bleeding. Regular monitoring of blood counts and liver function is typically required during methotrexate treatment.

Methotrexate is on the World Health Organization's List of Essential Medicines.

Methotrexate forms and dosage

Methotrexate is available in various forms, including tablets, injections, and oral solutions. 

For cancer treatment, Methotrexate is typically given by injection into a muscle or vein, and the dosage is based on the individual's body surface area or weight. The administration frequency and treatment duration will depend on the cancer type and stage and the individual's overall health.

For the treatment of non-cancerous conditions such as psoriasis and rheumatoid arthritis, Methotrexate is typically taken orally in tablet form once per week. The initial dosage is usually low and gradually increases over several weeks based on the individual's response and tolerance. The maximum dosage for non-cancerous conditions is generally lower than in cancer treatment.

Methotrexate can cause serious side effects if taken in too high a dose or too frequently.

Methotrexate should be taken with food or after a meal to minimize the risk of gastrointestinal side effects such as nausea and vomiting. It's important to drink lots of fluids while taking Methotrexate to help prevent kidney damage.

Methotrexate patent information

The original patent for Methotrexate has long expired, as it was first developed in the 1950s. However, subsequent patents have been granted for specific formulations and methods of delivery of Methotrexate.

For example, in the United States, the drug company Amgen has a patent for a specific formulation of Methotrexate used to treat rheumatoid arthritis. This patent is set to expire in 2024.

Methotrexate is available as a generic medication. Several companies manufacture and sell generic Methotrexate in various formulations, including tablets and injections. Some examples of generic methotrexate products include:

  • Methotrexate Sodium Injection, manufactured by Sandoz, Inc.
  • Methotrexate Tablets, manufactured by Teva Pharmaceuticals USA, Inc.
  • Methotrexate Injection, manufactured by Pfizer Inc.

Methotrexate wholesale price

The wholesale price of Methotrexate can vary depending on the formulation, dosage strength, and quantity purchased. Additionally, pricing can vary between different countries and regions.

In the United States, for example, the wholesale price for a vial of Methotrexate injection (25 mg/mL, 2 mL) can range from around $20 to $60, depending on the supplier and other factors. The wholesale price for a 2.5 mg tablet can range from around $0.05 to $0.20 per tablet.

In the United Kingdom, the NHS Drug Tariff lists the price of a 2.5 mg Methotrexate tablet as £0.07 per tablet (as of February 2023). The price of a 10 mg methotrexate tablet is listed as £0.26 per tablet. The cost of methotrexate injections can vary depending on the strength and manufacturer but typically range from around £1.50 to £3.00 per vial.

Methotrexate manufacturers and brands

Methotrexate is manufactured by several companies worldwide and is available under various brand names and generic formulations. Some of the commonly available brand names of Methotrexate include:

  • Trexall
  • Otrexup
  • Rasuvo
  • Rheumatrex
  • Methoblastin
  • Metoject

In addition to these brand names, Methotrexate is also available as a generic medication under its chemical name, Methotrexate.

Methotrexate is produced by many manufacturers, such as Bristol Myers Squibb, Mylan Pharmaceuticals, Norbrook Laboratories, Abic, Abraxis Pharmaceutical Products, Amneal Pharmaceuticals, Roxane Laboratories, Sandoz, Sun Pharmaceutical Industries, Accord Healthcare, AvKare and Zydus Pharmaceuticals (USA), among others.

Connecting to Methotrexate manufacturers and suppliers

Pharma buyers can simplify product sourcing and search for Methotrexate manufacturers and suppliers on Pipelinepharma using the following steps:

  1. Go to Pipelinepharma's online marketplace.
  2. Type "Methotrexate" into the search bar at the top of the page and click the magnifying glass icon.
  3. You will be taken to a page displaying search results for available Methotrexate products. On this page, you can filter the results by selecting helpful filters on the left-hand side of the screen.
  4. Select a suitable Methotrexate product card and click the "Send inquiry" button to submit your business request to a particular manufacturer or dossier owner.

More than 90 Methotrexate products are in the Pipelinepharma marketplace, listed under the Generics category. There are products with EU GMP approvals and several ready-to-file EU CTD dossiers.