Drug Name: Metformin
Chemical formulation: C4H11N5
Active ingredient: Metformin
Common/generic brand name: Metformin
Approved by FDA or not: FDA approved in 1995
Commonly marketed in: India, The United States, Canada, France, EU, Bangladesh, Egypt, Turkey, Mexico, China, and Morocco
Density: Metformin pills can be used alone or in combination with other oral anti-diabetic medications or insulin in adults. Metformin pills can be taken alone or in conjunction with insulin in children and adolescents as young as ten years old.
What is Metformin?
Metformin is a biguanide-class antihyperglycemic medication that is used to treat type 2 diabetes. Metformin is currently the first-line treatment for type 2 diabetes, and it is administered to at least 120 million individuals globally.
Metformin is classified as an antihyperglycemic medicine since it decreases blood glucose levels without causing hypoglycemia in people with type 2 diabetes. Metformin is a type of insulin sensitizer that lowers insulin resistance and lowers plasma fasting insulin levels by a clinically relevant amount. Another well-known advantage of this drug is that it helps you lose weight. Metformin is the medicine of choice for patients with type 2 diabetes who are fat.
Metformin is available in multiple forms:
Metformin is one of the prescription drugs that is availble as both oral capsule and injection.
Metformin Manufacturers & Wholesalers List
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How to use Metformin?
Patients with Diabetes Type 2 can take either an immediate-release or an extended-release Metformin therapy. An adult patient should take an initial dose of Metformin of 500 mg twice a day or 850 mg once a day for immediate-release therapy. Metformin is a drug that is taken by mouth. The patient should take 2000 mg per day in divided doses during the maintenance stage of the treatment. The highest daily dose of Metformin is 2550 mg. An adult patient should take the initial dose of 500 mg to 1000 mg once a day for an extended-release treatment. The highest daily dose is 2000 mg. Metformin is a drug that is taken by mouth. The patient should take the initial dose of 500 mg twice a day for Type 2 Diabetes in immediate-release medication if they are 10 years old or older.
Metformin Side effects -
Common side effects:
Stomach issues such as diarrhea, nausea, stomach discomfort, heartburn, and gas are some of the most prevalent metformin adverse effects. If the side effects are minor, they may fade gone in a matter of days or weeks. Talk to your doctor or pharmacist if they get more severe or don't go away.
Uncommon Side Effects:
Anxiety, blurred vision, chest discomfort, cold sweats, coma, confusion, cool, pale complexion, depression, dizziness, increased perspiration, slurred speech, shakiness, chest tightness, and extreme weariness or weakness are some of the less typical adverse effects.
Not Known and Rare Effects:
Some of the rare adverse effects include drunk-like behavior, difficulties concentrating, tiredness, lack of or loss of strength, restless sleep, and unusual sleepiness.
Special Warning or precaution for use
All patients should continue to eat a balanced diet with a consistent carbohydrate distribution throughout the day. Patients who are overweight should stick to their energy-restricted diet. Laboratory testing for diabetes monitoring should be done regularly. Metformin does not cause hypoglycemia when used alone, however, it should be used with caution when combined with insulin or other oral antidiabetics. Lactic acidosis should be made known to patients and/or caregivers.
Effect of Metformin on Pregnancy and Breastfeeding
Uncontrolled diabetes (gestational or permanent) during pregnancy is linked to an increased risk of congenital defects. When a patient expects to become pregnant or is pregnant, it is suggested that diabetes be managed with insulin rather than metformin to keep blood glucose levels as close to normal as possible, reducing the risk of fetal abnormalities.
Metformin is a drug that is excreted in human milk. Breastfed babies and infants showed no harmful consequences. Breast-feeding is not recommended when using metformin because there is insufficient data. The benefits of breastfeeding and the potential risk of detrimental effects on the kid should both be considered while deciding whether or not to stop.
FAQ About Metformin
1.What should be monitored while taking metformin?
Metformin concentrations must be monitored after 48 hours of consumption. Renal functions must be closely monitored every 3-6 months. Also, if the creatinine clearance drops below 15ml/min, then metformin must be discontinued.
2.What should be avoided while taking metformin?
Drinking alcohol along with metformin might lower blood sugar levels.
3.What should be known before giving metformin?
The doctor must be informed of all the natural medications and herbal supplements or any other medicines that you might be consuming.
4.What is bad news about metformin?
One of the rare side effects of metformin is lactic acidosis which is a major side effect. It can further cause lowering of blood pressure, rapid heart rate and vomiting or dehydration, and in worst cases death.