Ulinastatin is clinically in a highly purified form of a glycoprotein. It treats acute & chronic
pancreatitis, Stevens-burns, septic shock, Johnson syndrome, and toxic epidermal necrolysis. it
is also an effective urinary trypsin inhibitor that is isolated from healthy human urine or
synthetically produced in the lab.
Ulinastatin is sold under the brand names Roan, Miracle, Ulinase among others.
Guangdong Techpool Biochem. Pharma. Co., Ltd was assigned a patent in 2008 to treat SARS,
it was approved by FDA in 2014 for the treatment of Mild to severe Acute Pancreatitis, following
which it was in India to treat severe sepsis and acute pancreatitis since 2014. In China, it is
being used for acute respiratory distress syndrome.
Dosage and administration:
Ulinastatin is sold as in 100,000 IU vials for reconstitution in 100 ml of dextrose 5% or 100 ml of
0.9% normal saline. It is given by intravenous infusion over the course of one hour, one to three
times a day for three to five days. this dose is then adjusted based on the patient’s condition
and response to the initial dose.
The Price of Ulinastatin
In the international export market, the wholesale price of 100000 IU Injection is between USD
0.25 and USD 0.40 made by generic drug makers in China. However, the price of the same
medicine in India ranges from USD 15 & USD20.
How Ulinastatin works
Ulinastatin actions block digestive enzymes that help digestion. It also reduces the chemicals
involved in inflammation of the pancreas. As an acid-resistant protease inhibitor, from the high-
molecular-weight precursor I alpha T1, It inactivates many serine proteases, including trypsin,
chymotrypsin, kallikrein, plasmin, granulocyte elastase, cathepsin, thrombin, and several other
Found in the brain, liver, kidney, gastrointestinal tract, cartilage, plasma, ovarian follicular fluid,
amniotic fluid, and urine, its presence in tissues is due to diffusional uptake and retention
through cell surfaces. It also potentiates local anti-proteolytic activity on the extracellular matrix
during tissue remodeling. It also suppresses neutrophil accumulation and activity. The genes
and proteins regulated it is responsible for the inflammatory process, so it is not just a protease
inhibitor, but also prevents inflammation and cytokine-dependent signaling pathways. overall, it
plays an important role in the protection of organ injury during severe inflammation and also
inhibits tumor invasion and metastasis.
Finding Ulinastatin Manufacturers and Suppliers
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