Trimebutine:
Trimebutine is a medication used for the treatment of irritable bowel syndrome and other gastrointestinal disorders. It is for sale in various forms and sold under global brand names such as Debridat, Recutin, Polybutin, Trimedad, and Modulon. It was originally discovered by a pharmaceutical products manufacturing company and subsequently gained approval for use in many countries across the world, such as Canada and several others. However, it is notably not available in the United States as it has not been FDA approved. Currently, it has proved popular in the global marketplace with it being listed for sale by many trimebutine manufacturers and trimebutine suppliers. Where it is subsequently listed on the wholesale pharmaceutical products list of global distributors, at a variety of cost and price points.
Mechanism of action of Trimebutine:
Trimebutine belongs to a group of drugs termed spasmolytic agents. These serve to regulate both intestinal and colonic motility and are able to relieve abdominal pain through antimuscarinic and weak mu opioid agonist effects. At sufficiently elevated concentrations, trimebutine inhibits extracellular calcium ion influx in the smooth muscle cells through voltage-dependent L-type calcium ion channels and further calcium ion release from intracellular calcium ion stores. It does this by binding to the inactivated state of the calcium channel with high affinity, reducing calcium influx, which attenuates membrane depolarization and decreases colon peristalsis. It also serves to modulate potassium ion release and concentrations, furthering its clinical properties.
Form and dosage of Trimebutine:
The final form and packaging are dependent on the manufacturers and suppliers, as well as the specific distributors and order. However, trimebutine typically is for sale in forms including tablets, capsules, film-coated tablets, and modified-release tablets. In the treatment of gastrointestinal problems, the adult recommended dose consists of up to 600 mg daily taken in 3 divided doses (200 mg 3 times daily) before meals. Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. Therefore, it is important to follow the recommendation of the prescribing medical official and to review the manufacturers’ literature.
Trimebutine on Pipelinepharma:
Currently, at the time of writing, we have found 21 verified trimebutine manufacturers and trimebutine suppliers from our online global list of B2B sellers. These manufacturers, suppliers, and distributors are located in various countries including the European Union, Turkey, Argentina, and South Korea. Each company and their pharmaceutical products list listed on our online B2B platform has been verified by the Pipelinepharma team. This ensures seller reputability while reducing souring mileage and dead ends, allowing for a hassle-free buying experience.
Price of Trimebutine and how to buy:
As with other pharmaceutical products listed on the Pipelinepharma marketplace, the specific wholesale cost of trimebutine remains negotiable online between both B2B parties through the Pipelinepharma interface, or through a trusted system of your choice. This allows for flexibility and ease of negotiability. However, if desired the manufacturer or supplier may choose to include the desired cost for their product, facilitating trade and providing a baseline for further negotiation. If this is indicated, an ‘Accept’ and ‘Negotiate’ button will be shown, with a ‘Get offer’ button being displayed in the absence of a listed price.