Topotecan is a medication used to treat of severe ovarian cancer in individuals with disease progression or recurrence after platinum-based chemotherapy. In addition, it is used in mixture with cisplatin to treat stage IV-B, persistent, or reoccurring cervical cancer that is not responsive to curative treatment through surgery or radiation therapy. It is often used as a second-line therapy for small cell lung cancer that is responsive to treatment.Suppliers of topotecan market it in the form of oral capsules as well as powder and concentrates for injectable solutions. The developer and earliest manufacturer of topotecan medications was GlaxoSmithKline, who first introduced it into the market in 2007 under the trade name Hycamtin. It is currently available in over 80 countries globally. There are numerous producers and suppliers of topotecan worldwide, with the largest being well-known pharmaceutical companies GlaxoSmithKline, Teva, Fresenius Kabi, Cipla, Sagent Pharmaceuticals, Mylan, and Pfizer. Generic versions of the drug are also available on the global pharmaceutical market.

Topotecan is thought to exert its cytotoxic activity during in the S-phase of DNA synthesis and shares the same mode of action as irinotecan. Topoisomerase I causes reversible single - stranded breaks in DNA to reduce torsional stress. Topotecan blocks religation of these single strand breaks by attaching to the topoisomerase I-DNA complex. Due to the ternary complex's interference with the replication fork in motion, DNA double strand breakage and replication arrest are induced. The creation of this ternary complex finally results in apoptosis because mammalian cells are unable to effectively repair these double strand breaks. Topotecan intercalates between the upstream (1) and downstream (+1) base pairs to resemble a DNA base pair and attaches at the point of DNA cleavage.

The retail prices per 10 (1mg) topotecan tablets fall into an approximate range of 200 EUR to 500 EUR, whereas 4mg powder for injectable solutions can cost from 150 EUR to 300 EUR. The prices of Topotecan medications vary depending on the concentration of active ingredients in the formulation as well as supplier and manufacturer pricing. Also, the costs of Topotecan vary depending on manufacturer and supplier pricing, whether it is a generic or trade name formulation, concentration of the active ingredient in the formulation. Topotecan is available for sale from various Topotecan vendors at various costs. Topotecan suppliers, on the whole, are in favor of patient aid initiatives. The price of Topotecan is higher than that of such substitutes, owing largely to the more costly manufacturing process needed to produce it.

Making use of Pipelinepharma's worldwide B2B online marketplace for medications and other pharmaceuticals is the ideal approach to locate and acquire access to Topotecan manufacturers and suppliers. Buyers are advised that online sellers may attempt to market fraudulent versions of the generic drug, whereas Pipeline Pharma, through its pre-auditing and quality control procedures ensures that only verified Topotecan manufacturers and wholesalers enter our online marketplace, offering you a risk-free B2B pharmaceutical sales platform. Buyers are advised to buy from PipelinePharma. Finding reliable suppliers and manufacturers of particular medications like Topotecan can typically be a time-consuming challenge, but with Pipelinepharma's straightforward search engine and network of tested partners, the entire process becomes much simpler. Utilizing our built-in search engine, all you have to do to begin going is start looking for potential Topotecan suppliers or manufacturers. You may also use filters to narrow down your search results and look for Topotecan from particular nations.

Being a global B2B pharmaceutical online marketplace, Pipelinepharma is structured to simplify pharmaceutical deals by providing you with an intuitive interface that is easy to engage with. The selection of Topotecan offerings can be narrowed down with filters and easily weighed against one another according to medication prices and commercial terms. The advanced filters help you filter out the countries for this substance manufacturer and Topotecan suppliers that you are looking for. These also enable you to check the dossier status of this medicine and the GMP approvals of the different variants of Topotecan. Also, each manufacturer or supplier product description contains essential information about this substance, including clinical data, stability zones, and countries in which Topotecan is already registered. Manufacturers also have special delivery terms.

Suppose you are a pharmaceutical licensing company or a distributor. In that case, you can enter into deals or negotiations over these medicine offers with manufacturing companies after completing the free registration process and joining our online marketplace. This helps ensure that you conclude the pharmaceutical deal at a reasonable cost and achieve the best cost/benefit ratio for your company while bypassing lengthy sourcing, negotiation, and order process. Once you have finalized a deal, you can look forward to a long-lasting business relationship with the Topotecan suppliers. This way, the marketplace allows you as a distributor to skip the process of making a list of product manufacturers every time you are looking for in-licensing or distribution deals.

To keep up to the quality standards other than Good Manufacturing Practice approvals that this medicine manufacturers list has, we qualify their companies before they are boarded on the platform. This allows us to screen Topotecan manufacturers for the quality of the pharmaceutical products' dossiers and protect against the risk of possible malpractices.