Tolvaptan belongs to a class of medications called vasopressin V2 receptor antagonist. This drug is used to treat low sodium levels in the blood in people who have heart failure as they have higher serum levels of vasopressin, syndrome of inappropriate antidiuretic hormone or hormone imbalance and cirrhosis.
Tolvaptan improves urine flow without causing the body to lose too much sodium during urination.
Tolvaptan is advised as a prescription product, generic prescription product as well as mixture product.
Tolvaptan manufacturers sell this Drug under the Brand name of drug Jynarque, Samsca. This drug is available in dosage form of tablet which comes in 15 mg and 30 mg dosage strengths. The tolvaptan 15 mg tablet is blue, triangular, debossed with manufacturer’s name on one side and dosage strength on the other, whereas the tolvaptan 30 mg tablet is blue, round, debossed with manufacturer’s name on one side, and dosage strength on the other. Tolvaptan tablet is taken by mouth with or without food.
Before using this medication, the risk of taking the drug must be weighed against the benefits it provides. It is always recommended to consult a physician before taking Tolvaptan as this medication may interact with other drugs and few drugs can affect the removal of the tolvaptan from the body and affects its working.
The usual initial dose for Tolvaptan in adults suffering from hyponatremia (abnormal sodium levels in the blood) is 15 mg administered once daily, and the dose can be increased to 30 mg once daily after at least a day to a maximum of 60 mg once daily as required to achieve the desired level of sodium in the blood. Tolvaptan should not be administered for more than 30 days.
This medication is not recommended for pediatric use as safety and efficacy have not been established.
Tolvaptan tablets are recommended to store at 25° C (77° F), with excursions permitted between 15° C and 30° C (59° F - 86° F)
Wholesale Price of Tolvaptan
The wholesale price for 10 units of 30 mg Tolvaptan oral tablets is in between $ 3831.85 - 4110.79 with per unit cost comes at $ 383.19 - $ 411.08.
Brand drug of tolvaptan is categorized under patient assistance programs where the medication is sponsored by pharmaceutical companies or the manufacturer where the drug is provided for free or at discounted rates to low-income or underinsured people who fulfill the eligibility requirement.
Tolvaptan - Mechanism of Action
Tolvaptan is a vasopressin V2 receptor antagonist, vasopressin acts on the V2 receptors and blocks it. By blocking V2 receptors in the renal collecting ducts it prevents water absorption. This action ultimately results in an increase in urine volume and increases electrolyte-free water clearance to reduce intravascular volume and increases serum sodium levels. Tolvaptan works by increasing the amount of water released from the body as urine, removing fluid from the body helps in increasing the level of sodium in the blood.
Finding Tolvaptan Manufacturers and Suppliers
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