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Tiotropium bromide manufacturers

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tiotropium bromide

Inhalation powder 10 mcg, 18 mcg

Dossier type
Dossier status
Ready to file
Country of origin
European Union
GMP approvals
Ref: Spiriva Handihaler®
Manufacturer #252

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Tiotropium Bromide:

Tiotropium Bromide, also known by its popular brand name of Spiriva, is a long-acting bronchodilator medication used in the management of chronic obstructive pulmonary disease and asthma. Specifically, this drug is produced by manufacturers to proactively prevent periods of worsening rather than for those periods themselves. Tiotropium Bromide was originally patented in 1989 by a pharmaceutical products company and was subsequently submitted and gained regulatory approval for sale on the medical marketplace in 2002.

Currently, it is on the World Health Organization's List of Essential Medicines, indicating that it is a cost-efficient and effective medicine recommended for use in health systems across the globe. As such, it has become extremely popular, being the 82nd most commonly prescribed medication in the United States in 2017 with more than 9 million prescriptions. However, as of 2019, there is no generic version available in the United States, limiting the proliferation of Tiotropium Bromide manufacturers and Tiotropium Bromide suppliers. Regardless, Tiotropium Bromide is still frequently found available to order on the pharmaceutical products list of distributors across the global marketplace, where it can be found for sale and wholesale at a variety of cost and price points.

Method of action of Tiotropium Bromide:

Tiotropium Bromide belongs to a group of drugs that function as long-acting antimuscarinic bronchodilators, enabled through their antimuscarinic or anticholinergic properties. Tiotropium Bromide does not display selectivity for specific muscarinic receptors, however, when topically applied it functions as an antagonist of muscarinic receptors M1 to M5. It is primarily the inhibition of the M3 receptor which confers its clinical effects. As the M3 receptor is located on smooth muscle cells and submucosal glands which subsequently leads to a reduction in smooth muscle contraction and mucus secretion and thus produces the observed bronchodilator effect.

Form and dosage of Tiotropium Bromide:

The final form and packaging of Tiotropium Bromide is dependent on the manufacturers and suppliers, as well as the specific distributor and order. Tiotropium Bromide prominently comes in the form of powder for inhalation and capsules. The typical prescribed dose for the maintenance treatment of chronic obstructive pulmonary disease is 5 micrograms inhaled once daily. For further information and possible side effects please refer to the manufacturers’ instructions or the prescribing healthcare provider.

Tiotropium Bromide on Pipelinepharma:

Currently, at the time of writing, we have found 3 verified tiotropium bromide manufacturers and tiotropium bromide suppliers from our online global list of B2B sellers. These manufacturers, suppliers, and distributors are located in various countries including Turkey and China. Each company and their pharmaceutical products list displayed on our online B2B platform has been verified by the Pipelinepharma team. This ensures seller reputability and reduces sourcing mileage, allowing for a fluent business experience for all involved parties.

Price of Tiotropium Bromide and how to buy:

A cursory search online reveals an approximate wholesale cost for Tiotropium Bromide to be USD 45.54 for 18 microgram capsules x 30 and a price of USD 30.03 for 2.5 microgram x 30 inhalation solution. These values are indicated for the NHS in the UK. As such they are only intended to serve as a generalization of the current market conditions.

Although the prices on the B2B wholesale Pipelinepharma marketplace remain confidential between both B2B parties, the seller may choose to list the desired price to facilitate the online transaction. If so, an ‘Accept’ and ‘Negotiate’ button will be displayed through the online interface, with a ‘Get offer’ button being shown in the absence.