Tazobactam Sodium, usually available under the trade name “Zosyn”, is a beta-lactamase inhibitor antibiotic that stops other antibiotics from being broken down by beta-lactamase enzymes. It is used in the treatment of bacterial infections like stomach infections, skin infections, pneumonia, and severe uterine infections. This pharmaceutical medicine is used in combination with Piperacillin and Ceftolozane. Tazobactam Sodium injection is available as a powder that must be mixed with liquid before being given intravenously (into a vein). It is typically administered every 6 hours, although children 9 months and older may be administered every 8 hours. The duration of treatment is determined by your overall health, the type of infection, and how well the patient responds to the drug. After the health of the patient improves, the doctor may move them to a different antibiotic that can be taken orally to finish your treatment. This pharmaceutical medicine may have some side effects. Some of the common side effects associated with it include diarrhea constipation, nausea, vomiting, heartburn, stomach pain, fever, insomnia, and mouth sores. This drug falls into the FDA pregnancy risk category C. It should be taken with caution during pregnancy. Treatment benefits should be considered against any potential risks to the fetus. Its secretion in human milk has not been examined. Due to a lack of safety evidence, it should be taken with caution in breastfeeding women. The FDA authorized Piperacillin-Tazobactam in 1994, and Ceftolozane-Tazobactam in 2014, offering broader antibacterial coverage for gram-negative infections. The FDA authorized Ceftolozane-Tazobactam in June 2019 for the treatment of hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia.

Tazobactam Sodium inhibits beta-lactamase and prevents Piperacillin degradation. As a result, Tazobactam is given in conjunction with Piperacillin to increase the action of piperacillin in eradicating bacterial infections.

Tazobactam Sodium intravenous powder for injection (3 g-0.375 g) costs roughly $35 for a supply of 10 powders for injection. The price depends on the different pharmacies you visit.

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