SPECTINOMYCIN HYDROCHLORIDE
Spectinomycin Hydrochloride is the hydrochloride salt of Spectinomycin. It is an aminocyclitol
antibiotic derived from Streptomyces spectabilis, and it has bactericidal properties. When
injected into a muscle It is most commonly used to treat gonorrhea infections. Spectinomycin
Hydrochloride belongs to the aminocyclitol class of medicines that benefit the patient by stopping
the making of protein by harmful bacteria. Streptomyces spectabilis are used to make
Spectinomycin Hydrochloride, and is active against gram-negative bacteria. Spectinomycin
Hydrochloride is also given to patients whose previous antibiotic therapy failed to cure the
infection.
Spectinomycin Hydrochloride is sold under the brand names Trobicin, Myspec, Spectrum among
others.
Upjohn Company’s researchers discovered Spectinomycin in 1961. Its safety and efficacy
profile has led to it finding a place on the World Health Organization's List of Essential
Medicines, as among the safest and most effective medicines required in any health system. It
is not available in the United States anymore.
Dosage and Administration
Spectinomycin is sold as a powder for injection for preparation of a drug for Intramuscular
Injection. It comes as a sterile powder of 2 grams for reconstitution with 3.2 mL of Sterile Water
for Injection, USP. After adding Sterile Water for Injection, the vials should be stirred vigorously
immediately and before the withdrawing dose. A 20-gauge needle with a disposable syringe is
the recommended way to administer.
When being given as an Intramuscular injection, the dose for adults, both Men, and Women is 5
mL, injected intramuscularly for a 2-gram dose, deep into the upper outer quadrant of the gluteal
muscle. In geographic areas with high antibiotic resistance, the initial dose starts with 4 grams
or 10 mL, where the the10-mL injection is divided between two gluteal injection sites.
The price of Spectinomycin hydrochloride
Spectinomycin powder, BioReagent, suitable for cell culture is sold for USD100 for a supply of
5g. for the injection containing Spectinomycin, the consumer in India pays USD 2.6 for a supply
of one, 2gm injection. This medicine is approved for sale in the USA.
How does it work?
Spectinomycin hydrochloride actions bind to the bacterial 30S ribosomal subunit. There they
inhibit peptide elongation and protein synthesis. This leads to bacterial cell death.
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