Sparfloxacin is a fluoroquinolone antibiotic. It is used in the treatment of bacterial infections,
specifically community-acquired lower respiratory tract infections like acute sinusitis,
exacerbations of chronic bronchitis caused by susceptible bacteria, and community-acquired
pneumonia. it is active against Chlamydia pneumonia, Haemophilus parainfluenzae,
Haemophilus influenza, Moraxella catarrhalis, Streptococcus pneumonia, Mycoplasma
pneumonia, Enterobacter cloacae, Klebsiella pneumonia, and Staphylococcus aureus.
However, it has been withdrawn from sales in the USA.
Sparfloxacin is sold under the brand names Zagam, Zagam Respipac among others.
Rhone DPC Europe patented Sparfloxacin in 1985 and approved it for medical use in
1993. However, it is no longer available in the United States due to a controversial safety profile.
Dosage and Administration
Sparfloxacin is sold as 200mg tablets in a blister pack of 11 or a bottle of 55 tablets. It is taken
orally with or without food, however, the patient has to take antacids containing magnesium and
aluminum or sucralfate or Videx, or the pediatric powder for oral solution, 4 hours after taking
Sparfloxacin. For patients with normal renal function, the recommended daily dose is, two 200-
mg tablets, as the loading dose on day one, followed by one 200-mg tablet, every 24 hours, for
a total of 10 days of therapy. For patients with renal impairment whose creatinine clearance is
lower than 50 mL per minute, the loading dose is two 200-mg tablets on day 1, followed by one
200-mg tablet, every 48 hours, for a total of 9 days of therapy.
The PRICE of Sparfloxacin
In India, the price of the generic version of the 200 mg tablets cost USD 13.06. however, there are
several drug manufacturers of Sparfloxacin, and is available at much lower prices too. It is not
approved for sale in the USA anymore.
How does it work?
Sparfloxacin is quinolones and fluoroquinolones. Its main action is bactericidal, which is actively
killing bacteria. It works by inhibiting the bacterial DNA gyrase or the topoisomerase IV enzyme.
This in turn inhibits DNA replication and transcription. It easily enters the cells, thus is often
used to treat intracellular pathogens such as Legionella pneumophila and Mycoplasma
pneumonia. DNA gyrase is the main target for many gram-negative bacteria, whereas
topoisomerase IV is the target for many gram-positive bacteria.
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