Sorafenib tosylate is an organosulfonate salt containing a Sorafenib. Sorafenib Tosylate is
approved to treat Hepatocellular carcinoma, a type of liver cancer that which cannot be
operation upon. It is primary malignancy of the liver and occurs mostly in people with history
of chronic liver disease and cirrhosis.
Renal cell carcinoma, a type of advanced kidney cancer, Thyroid cancer in patients with
progressive, recurrent, or metastatic cancer which does not respond radioactive iodine
treatment. It also has been studied for treating other cancers. Sorafenib tosylate actions stop
cancer cells from dividing and prevents the growth of new blood vessels needed by tumors
to grow. Sorafenib Tosylate is both a kinase inhibitor and a antiangiogenesis agent.
Sorafenib Tosylate is commonly sold under the brand name Nexavar.
Bayer and Onyx were given the FDA approval of drug Application for Sorafenib for treating
Advanced Renal Cell Carcinoma in 2005.
Forms and Dosage:
Sorafenib Tosylate is sold as 200 mg tablet and the normal recommended dose is 400mg
per dose, two times a day for Renal Cell Carcinoma, Hepatocellular Carcinoma and Thyroid
The price of Sorafenib Tosylate:
The price of this medicine is between USD 20 and USD 100 for a supply of 30 tablets of
200mg. in the Western markets, like USA, the same supply cost around USD920.
How does Sorafenib Tosylate work?
Sorafenib Tosylate is a multiple tyrosine kinase inhibitor. The tosylate salt of sorafenib, a
synthetic compound. It is designed to target growth signaling and angiogenesis. Sorafenib
blocks the enzyme RAF kinase. This is a critical component of the many signaling pathways
that control cell division and proliferation. In addition, It also inhibits the VEGFR-2/PDGFR-
beta signaling cascade. This eventually results in blocking tumor angiogenesis. Through the
blocking action of these enzymes, it helps stop and prevent the growth of cancer cells.
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