Sodium Citrate is given to patients with kidney-related problems primarily to make their urine less acidic. Sodium citrate makes blood and urine more less acidic, which helps prevent kidney stones. Less acidic urine helps the kidneys get rid of uric acid, thereby preventing the formation of gout and kidney stones. Sodium citrate also prevents and treats certain metabolic acidosis caused by kidney disease.
Sodium citrate’s common brand names include Bicitra, Cytra-2, Oracit, Shohl's, Liqui-DualCitra, Oracit, Virtrate to name a few.
World Health organization’s global study revealed that between 2005 and 2015, a total of 5 million people died of kidney-related diseases and a massive 10% of the global population suffers from chronic kidney diseases. Due to this life-threatening disease’s prevalence throughout the world, Sodium citrate drug is manufactured and marketed by companies many around the world.
In 1914, when the Doctors were working on perfecting blood transfusions, one of these Doctors, the Belgian physician Albert Hustin, and Argentinian doctor Luis Agote, discovered the anticoagulant properties of sodium citrate but there were still some issues. Later on, Dr. Richard Lewisohn of New York's Mount Sinai Hospital solved that problem when he discovered the concentration at which sodium citrate could keep blood liquid without poisoning the transfusion recipient.
Sodium citrate is sold as an oral solution. It is administered orally, usually 4 times a day or as directed by your doctor. A normal dose for adults is between 2 to 6 teaspoons (10 to 30 ml) of diluted in 30 to 90 ml of water. Children are given 5 to 15 ml of liquid in 30 to 90 ml of water.
What is the cost of Sodium Citrate?
The cost of Sodium Citrate can vary greatly from one country to the next. In the United States, the cost of 500 grams starts from $25, whereas the National Health Service in the United Kingdom pays around £15. In Asia, China, and India, the prices are significantly lower at USD3 – USD 7 per 1 500 grams of Sodium Citrate.
How does it work?
Sodium Citrate is one of three sodium salts with alkalinizing activity. When the human body digests sodium citrate, it starts a process in the body that neutralizes excess acid in the blood and urine, resulting in an increase in the plasma bicarbonate concentration. This raising of blood pH thus paving the way for the reversal of acidosis. Free sodium in sodium citrate increases intravascular blood volume and creating an anti-urolithic effect.
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Baxter Labs, Medsep Corporation, Haemonetics Corporation, Cutter Med & Biol, Division Of Miles Canada Ltd., Fenwal, Inc., Fresenius Kabi USA, LLC,
Generic product makers:
Laboratorios Grifols Sa, Terumo Bct, Ltd
OTC product makers: Warner Lambert Canada Inc. , Smithkline Beecham Consumer Healthcare, Division Of Smithkline Beecham Inc. , Alva-Amco Pharmacal Companies, Inc.