Silybum marianum also called Cardus Marianus or blessed milk or Marian or Mary or Saint
Mary's or Mediterranean milk or variegated or Scotch thistle is an annual or biennial plant of the
family Asteraceae. Since ancient times, it is known for its active flavonolignans constituents
groups, called Silymarin. It is found only in the seed shell. Silybum marianum has liver-
protective and regenerative properties, in addition to its antioxidant effects. It is also used to
treat diabetes in combination with frontline therapy, for liver disease although it has yet to be
Silybum marianum is sold under the brand name Puritan's Pride, Jarrow Formulas, FarmHaven,
and Nature’s bounty among others.
Silybum marianum research started in Germany in the 1950s. The FDA is yet to review Silybum
marianum for safety or effectiveness.
Dosages and administration
Milk thistle is safe in dosages of 420 mg per day. it is taken orally in divided doses for up to 41
months. There are also daily doses of 12 to 15 g of dry fruits for dyspepsia and disorders of the
biliary system. its extract containing 200 to 400 mg per day is effective in various liver disorders.
This product is consumed as directly as it comes in several forms. When unsure about the
quantity and in case of adverse side effects, the patient should immediately see a doctor.
The price of Silybum marianum
It is sold OTC, and Prescribed for Life. 4 oz (113 g) Milk Thistle with 80% Silymarin extracted
Natural Seed Extract Powder cost $2499and Milk Thistle Extract Powder 250 Grams costs
$2496. In the developing world countries, for example in India, a kilo of this powder can cost as
low as USD3, depending on the brand, quality, and purity.
How does it work?
Silymarin has hepatoprotective and regenerative properties and action. Its actions reduce FR
formed by toxins that damage the cell membranes, it also competitively inhibits hepatocyte
external cell membrane modification. By forming a complex it stops the entrance of toxins into
the interior of liver cells. Additionally, it metabolically stimulates hepatic cells and activates the
RNA biosynthesis of ribosomes to stimulate protein formation.
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