Saxagliptin is used to lower blood sugar levels in patients with type 2 diabetes. Saxagliptin is
called a dipeptidyl peptidase-4 (DPP-4) inhibitor. Amongst people with type-2 diabetes and
high blood sugar tend to develop serious or life-threatening complications. These
complications impact the healthy functioning of vital organs causing heart disease, stroke,
kidney problems, nerve damage, and eye problems. Saxagliptin therapy decreases the risk of
probability of a heart attack, stroke, and other types 2 related complications affecting kidney
failure, nerve damage, eye problems, including changes or loss of vision, or gum disease.
patients suffering from type 2 diabetes are not able to produce enough insulin, Saxagliptin
works by increasing the amount of insulin produced by the body after meals.
Saxagliptin, sold under the brand name Onglyza amongst others.
The incidence of type 2 diabetes has increased significantly since 1960 as a function of
obesity. Even in 2015, Approximately 392 million people were diagnosed with it compared
to 30 million in only 30 years ago. Although it mostly affects people in their middle or older
age, rates of type 2 diabetes are increasing in young people. It is known the reduce life
expectancy by 10 years.
Bristol-Myers Squibb conducted the early development, later in 2007, AstraZeneca joined
with Bristol-Myers Squibb to co-develop the final compound and marketing of the drug. The
FDA approved saxagliptin with the brand name Onglyza in 2009. The European Medicines
Agency In 2006 licensed Saxagliptin for use throughout the European Union, Bristol-Myers
Squibb announced that Otsuka Pharmaceutical Co has been granted exclusive rights to
develop and commercialize the compound in Japan.
Dosage Forms & Strengths
Saxagliptin is sold in a tablet of 2.5mg and 5mg strength. In the treatment of Diabetes
Mellitus Type 2 the patients are recommended a dose of 2.5-5 mg daily.
The cost of Saxagliptin
In the USA, a consumer has to pay approximately $203 for the 2.5- or 5.0-mg tablets for a
month’s supply. In the UK, the 2.5mg tablets cost 32 pounds for a supply of 28 pills.
How does Saxagliptin work?
Saxagliptin actions increase the amount of insulin produced after meals when blood sugar is
high. Saxagliptin is from a class of medications called dipeptidyl peptidase-4 (DPP-4)
inhibitor antidiabetic. DPP-4 inhibitors work by affecting the action of natural hormones in
the body called Incretins. These Incretins are responsible for decreased blood sugar by
increasing the consumption of sugar by the body, mainly through increasing insulin
production in the pancreas. It also signals the liver to stop producing sugar when there is too
much sugar in the blood and by reducing the production of sugar by the liver.
Finding Saxagliptin Manufacturers and Saxagliptin Suppliers
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Onglyza, Qternmet XR, Qtern, Kombiglyze XR