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Country of origin : China
1 products found

pp-120

Tablets

Dossier type
CTD
Dossier status
Under development
Country of origin
China
GMP approvals
China
Comments
Indication: KRAS G12C-mutant advanced solid tumors, primarily non-small cell lung cancer (NSCLC) and potentially other KRAS-driven solid tumors in relapsed/refractory settings Clinical stage: Phase 1/2 clinical development Modality: Small molecule Mechanism / Target: Selective KRAS G12C covalent inhibitor, locking KRAS in its inactive GDP-bound state and suppressing downstream MAPK signaling (RAF–MEK–ERK pathway) Route / form: Oral tablet (expected solid oral formulation) Differentiation: Next-generation KRAS G12C inhibitor designed to overcome resistance mechanisms seen with first-wave KRAS inhibitors; aims for improved potency and durability of response in KRAS-driven tumors; potential combination backbone therapy with EGFR or MEK inhibitors
Manufacturer #39107

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