Otilonium bromide is a calcium channel blocker and an antimuscarinic medication. it is
prescribed to relieve spasmodic pain of the gut, especially for those suffering from irritable
bowel syndrome. Otilonium bromide belong to a class of synthetic anticholinergics called the
quaternary ammonium compounds which are primarily used in the treatment of functional bowel
disorders, as it exerts an intense antispasmodic action on the digestive tract’s smooth muscles.
It is always sold in combination with SIMETHICONE and its actions have not yet been full
Otilonium bromide is sold under the brand name Spasmoctyl 40, Doralin among others.
Menarini Sas developed and filed for patent in Italy for using it for topical application in the
gastro-intestinal tract and related appropriate uses in 1986. Santa Farma Ilac Sanayi AS is the
current patent assignee for Oral compositions combining simethicone with bulk density and with
improved characteristics for dissolution. This medicine is not approved for sale in the USA.
DOSAGE AND ADMINISTRATION
Otilonium bromide is sold in Europe and the rest of the world as tablets commonly I 40mg
prescription strength. It has to be take on an empty stomach, precisely as suggested by the
doctor. The patient must take care not to take antacids within two hours of taking Otilonium
Bromide and the course should continue until the doctor feesl the needs. The usual
recommended dose for adults is 120 mg daily, maximum. If a dose is missed, it should be taken
at the earliest but not too close to the next dose or two doses combined for make up for the lost
The price of Otilonium bromide
In India, each 40 mg tablets of Otilonium bromide cost around USD 0.20, taking the cost of a
monthly supply to USD 15. In the European market, the cost of 10 tablets of 40mg is around
USD 19 for a branded version of Otilonium bromide and USD 1.56 for a generic version of the
How does it work?
Otilonium bromide actions block Ca2+ entry through L-type Ca2+ channels. It interferes with
intracytoplasmatic Ca2+ mobilization necessary for SMC contraction. The result is the prevention
of excessive bowel contractions and abdominal cramps. It also blocks T-type Ca2+ channels
while interfering with the muscarinic responses. It also interacts with the tachykinin receptors
on SMC and primary afferent neurons. The combined effect results in the reduction of motility
and abdominal pain.
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