Omega-3 acid ethyl esters
Omega-3 acid ethyl esters are ethyl esters of the omega-3 fatty acids eicosapentaenoic acid
and docosahexaenoic acid, which naturally occur in fish and extracted as an oil. In combination
with diet, they treat high blood triglycerides which aim to reduce the risk of pancreatitis. Omega-
3 acid ethyl esters are also used if the blood fat levels have not been fully controlled by diet
changes, exercise, decreasing alcohol intake, weight loss regimen, reducing blood sugar in
diabetics, and regulating your thyroid hormone levels. Lowering triglycerides and increasing
"good" cholesterol reduces the risk for strokes and heart attacks. Omega-3 acid ethyl esters are
taken orally as medicines or supplements.
Omega-3 acid ethyl esters are sold under the brand names Lovaza and Omtryg among others
Pronova made Omega-3 acid ethyl esters were approved in the United States in 2004. Its
medicines were approved for medical use in the EU in 2000. Trygg Pharma, Inc’s Omtryg
omega-3 acid ethyl esters were one of the most commonly prescribed to more than 3 million
people in the United States. However, NHS Scotland prefers it less than statins and does not
recommend its use due to lack of evidence for cardiovascular conditions.
Dosage and administration
Omega-3 acid ethyl esters are supplied as a liquid-filled gel capsule and used orally. Each
capsule comprises 1.2 grams of omega-3-acid ethyl esters type A, liquid concentrate of 900 mg
omega-3-acid ethyl esters at least, and are predominantly a combination of approximately 465
mg of EPA and approximately 375 mg of DHA.
Prior to starting the use of this medicine, the patient is assessed for triglyceride levels, and
tested for diabetes mellitus, hypothyroidism, or medications of high triglyceride levels, and
managed as needed. The patient must have been on a lipid-lowering diet before and maintain
that diet for using this therapy. The recommended daily dose is 4 capsules per day, taken as a
single dose four times a day. the capsules have to be swallowed whole and should not be
broken open, crushed, or dissolved, or chewed.
Price of Omega-3 acid ethyl esters
In the international market, the consumers have to pay a retail price of $208.22 for the supply of
120 capsules of 1g strength. In India, the consumers have to pay a retail price of USD 4 for the
supply of 15 capsules of 1g strength.
How do Omega-3 acid ethyl esters work?
Omega-3 acid ethyl esters lower triglyceride production by the liver however, this has been fully
understood yet. It also inhibits Acyl-CoA:1,2-diacylglycerol acyltransferase, reducing triglyceride
synthesis while improving paroxysmal beta-oxidation, this results in an increase in fat aside from
metabolism2. It also inhibits the release of fatty acids by competing for enzymes involved in the
synthesis of triglycerides and increases triglyceride clearance by increasing the activity of
lipoprotein lipase. Its actions also decrease the production of VLDL-C2.
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