Iohexol contains iodine and belongs to a class of drugs known as non-ionic iodinated contrast media or dyes which is an effective non-ionic, water-soluble contrast agent. Iohexol is used in myelography, arthrography, nephron angiography, arteriography, and other radiographic procedures.
This medication is advised as a prescription product only.
Iohexol is marketed by manufacturers under the Brand name of Omnipaque, Oraltag, Nycodenz. This drug is available in the dosage form of an injection solution, solution, liquid. Iohexol solution is administered via a wide variety of routes like intravenously, intravascularly, intra-articularly, oral, rectal, intrathecal, and subarachnoid. Intrathecal half-life is 3.4 hours and Intravascular half-life is approximately 2 hours with normal renal function.
Iohexol is available in a dosage strength of 10 mL, 20 mL, 50 mL, 100 mL supplied in a glass vial or glass bottle.
The Intrathecal administration of Iohexol in adults is 180 mg or 240 mg or 300 mg of iodine per mL for lumbar, thoracic, cervical, and total columnar myelography. In pediatrics, Iohexol 180 mg of iodine per mL is administered intravascularly for lumbar, thoracic, cervical, and total columnar myelography.
The intravascular administration of iohexol in adults is 140 mg of iodine per mL is given for intra-arterial digital subtraction angiography of the head, neck, abdominal, renal, and peripheral vessels. Iohexol 240 is administered intravascularly for CT head imaging and for peripheral venography. In pediatrics, iohexol 240 is administered for CT head and body imaging, and Iohexol 300 is used for angiocardiography, excretory urography, and CT head and body imaging.
For oral and rectal administration, iohexol 350 is given for oral radiographic examination of the gastrointestinal tract while iohexol 180, 240, 300 is administered orally and rectally for radiographic examination of the gastrointestinal tract.
Iohexol is recommended to store at a controlled room temperature of 20° C - 25° C (68° F - 77° F). Excursions permitted to 15° C to 30° C (59° F to 86° F).
Wholesale Price of Iohexol
The wholesale price of Iohexol 350 injectable solution (350 mg/mL) is around $ 130.08 for a supply of 125 milliliters with per unit cost at $ 1.04, and the cost for 500 milliliters is priced between $ 536.50 - $ 588.98 with unit price available for $ 1.07 - $ 1.18 depending up on the pharmacy one visit.
Iohexol - Mechanism of Action
The iodine atoms in iohexol provide attenuation of X-rays in direct proportion to the concentration of iohexol. Since concentration changes over time, iohexol provides time-dependent image contrast which may assist in visualizing body structures.
Iohexol is absorbed from cerebrospinal fluid (CSF) into the bloodstream and is eliminated by renal excretion. No significant metabolism, deiodination, or biotransformation occurs. After intrathecal administration into the subarachnoid space, diffusion of iohexol in the CSF allows the visualization of the subarachnoid spaces of the head and spinal canal. After intravascular administration, iohexol makes opaque vessels in its path of flow, allowing visualization of the internal structures until significant hemodilution occurs.
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