HYPROMELLOSE
Hypromellose is popularly called artificial tears. It prevents corneal damage in patients with kerato-
conjunctivitis sicca accompanying rheumatoid arthritis, xerophthalmias, or keratitis. It moistens hard
contact lenses and lubricates artificial eyes during Gonioscopy procedures. Hypromellose actions
provide relief of dry eye conditions immediate. These include dry eye conditions associated with the use
of TVs, infrequent blinking, some therapies, pollution, and a dry atmosphere. It is used as eye drops and
a component of controlled-delivery in oral medicaments. It is used in HPMC matrices and oral controlled
delivery systems.
It is also used in a wide range of commercial products. As a food additive, Hypromellose is used as a
thickening, suspending agent emulsifier, and an animal gelatin alternative. Hypromellose has other uses
such as acting as a thickening agent, binder, hydrophilic matrix material, and film former.
Hypromellose is sold under the brand names Hymelose, Hyprosol, Ikleen amongst others.
Yea-Sheng Yang filed for the first patent in relation to Hypromellose in 2002. Noack Robert M. later filed
a patent for Oral extended-release tablets and methods of making and using the same in 2002. Since it is
essential to mix ingredients, Hypromellose is involved in several formulations and patents by several
companies around the world.
Dosage and administration
Hypromellose is sold as oral & ophthalmic solution in 18 mg/1mL and 25 mg/1mL strengths. The dose
for adults, children, and the elderly is one or two drops topically instilled into the eye, three times a day
or directed by the doctors.
The price of Hypromellose
In the USA, consumers have to pay an average retail price of USD 24.30 for a supply of 15 milliliters. The
price of 0.3%/ml eye drops cost USD 0.35 for a supply of 10ml.
How does it work?
Hypromellose increases corneal wetting by the stabilization and thickening of the precorneal tear film. Its
actions also prolong the tear film breakdown time, which is very short in people with dry eye conditions.
Its ingredients also lubricate and protect the eye. Hypromellose’s surface-active properties stabilize the
tear film and increase tear viscosity, resulting in prevention and delay in tear evaporation and delay tear
drainage. In patients with dry eyes caused by mucin deficiency, its surface activity and its adsorptive
capacity make hypromellose ideal for use. Hypromellose actions create an aqueous solution, a reduced
surface tension, and an increased level of viscosity. Hypromellose provides ample moisture to the
cornea and conjunctiva.
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