Vitamin B12 deficiency and cyanide poisoning are treated with hydroxocobalamin, a synthetic version of the vitamin.
Vitamin B12a, or hydroxycobalamin, is an injectable form of vitamin B 12 that has been used to treat vitamin B 12 deficiency.
For the prevention and treatment of vitamin B12 deficiency caused by alcohol addiction, malabsorption, tapeworm infestation, celiac disease, thyroid issues, hepatic-biliary tract disease, persistent diarrhea, ileal resection, stomach cancer, kidney problems, protracted stress, vegan diets, macrobiotic diets, or other strict diets. Also for the treatment of cyanide poisoning, whether known or suspected.
Cyanide is converted to the far less deadly cyanocobalamin by hydroxocobalamin. Cyanocobalamin is excreted by the kidneys. Because of its low adverse risk profile, the rapid start of the action, and convenience of application in the prehospital context, hydroxocobalamin became the primary line of treatment.
Vitamin B12 in the form of hydroxocobalamin is a synthetic, injectable version. Hydroxocobalamin is a precursor to two cofactors or vitamins (Vitamin B12 and Methylcobalamin), both of which are important in human biology. The conversion of methylmalonate to succinate requires vitamin B12. As a result, a lack of this enzyme may interfere with the formation of lipoprotein in myelin sheath tissue, resulting in neurological disorders. Methylcobalamin, the second cofactor, is required for the conversion of homocysteine to methionine, which is required for folic acid metabolism. Tetrahydrafolate deficiency causes decreased thymidylate synthesis, which leads to decreased DNA synthesis, which is required for cell development.
Vitamin B12 is also involved in the reduction of sulphydryl groups, with a shortage resulting in lower levels of reduced SH in erythrocytes and liver cells. Vitamin B12 is a coenzyme that helps with a variety of metabolic processes, including fat and glucose metabolism and protein synthesis. It is required for cell development, replication, hematopoiesis, nucleoprotein synthesis, and myelin production. This is owing to its effects on methionine, folic acid, and malonic acid metabolism.
Hydroxocobalamin was discovered for the first time in 1949. It is listed as one of the most important medicine by the World Health Organization. A generic version of hydroxocobalamin is available. It's made commercially with one of several strains of bacteria.
The acute toxicity profile of hydroxocobalamin is typically regarded as safe with local and systemic exposure, according to the literature. Because of hydroxocobalamin's ability to rapidly scavenge and detoxify cyanide through chelation, several acute animal and human studies using suprapharmacological hydroxocobalamin doses as high as 140 mg/kg have been conducted to support its use as an intravenous (IV) treatment for cyanide exposure. The use of hydroxocobalamin as an injection for the treatment of cyanide poisoning was approved by the US FDA at the end of 2006.
The medication induces chromaturia, a crimson tint of the urine that can resemble blood in the urine.
How does Hydroxocobalamin work?
Deoxyadenosylcobalamin, methylcobalamin, hydroxocobalamin, and cyanocobalamin are the four primary forms of vitamin B12, commonly known as cobalamins. The body typically uses two of them, methylcobalamin and 5-deoxyadenosyl cobalamin. This enzyme is involved in the conversion of homocysteine to methionine, an amino acid. DNA methylation, in turn, necessitates methionine. The enzyme that converts L-methylmalonyl-CoA to succinyl-CoA requires 5-deoxyadenosyl cobalamin as a cofactor. This is a crucial stage in the process of extracting energy from proteins and lipids. Succinyl CoA is also required for the formation of hemoglobin, the molecule that transports oxygen in red blood cells.
The Wholesale Price of Hydroxocobalamin
An online search for the wholesale price for sale of Hydroxocobalamin for distributors will reveal a wide range of costs. It will vary from store to store depending on your visit and the country of the wholesale market.
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