Drotaverine, also known by its INN name of drotaverin, is a medication belonging to the antispasmodic family of drugs. It is structurally related to papaverine and is used to increase cervical dilation during childbirth as well as in the treatment of functional bowel disorders and alleviating pain in renal colic. Although widespread regulatory approval is generally lacking due to drug effectiveness and safety concerns, with many clinical trials continually ongoing. It can be found on drotaverine manufacturers and drotaverine suppliers pharmaceutical products list, where it is frequently listed for sale and wholesale by distributors on the global marketplace at a variety of cost and price points. Some notable company brand names that are produced by manufacturers include Drotin, No-Spa, and Taverin.
Method of action of drotaverine:
Drotaverine belongs to a group of drugs and medications termed antispasmodic. This refers to pharmaceutical products or other agents that are capable of suppressing muscle spasms. To this effect, drotaverine has no anticholinergic effects but functions as a selective inhibitor of phosphodiesterase 4. This serves to inhibit the phosphodiesterase mediated hydrolysis of cAMP, increasing cAMP concentration, while decreasing Ca uptake to the cell and changing the distribution of calcium. Additionally, it may also exhibit minor allosteric calcium channel blocking properties, further contributing to its function.
Form and dosage of drotaverine:
As with all drugs, the final form and packaging of drotaverine is dependent on the manufacturers and suppliers, as well as the specific distributors and order. However, typically it is available for sale in different forms such as ampoules, tablets, solution for injection, tablets, film-coated tablets, and vials. In most jurisdictions a prescription is required to obtain drotaverine, as such, the accompanying advice of the medical professional on dosing should be followed as it is highly dependent on the specific underlying ailment. A typical regiment, as described by manufacturers and literature, in the treatment of renal colic pain is 40-80 mg taken 3 times a day for adults.
Drotaverine on Pipelinepharma:
Currently, at the time of writing, we have found 22 verified drotaverine manufacturers and drotaverine suppliers from our online global list of B2B sellers. These manufacturers, suppliers, and distributors have drotaverine available for wholesale B2B order and are located in various countries including the European Union and the United States. Each seller listed on our online company marketplace has been verified by the Pipelinepharma team according to strict quality control. This ensures the seriousness of the provider, facilitating buyer ease and reducing sourcing mileage.
Price of drotaverine and how to buy:
The cost of drotaverine is highly dependent on numerous factors such as organisation, manufacturers, quantity, and market. However, a cursory search online reveals that 10 40 mg generic drotaverine tablets are priced wholesale at approximately USD 0.34 by the pharmaceutical products company Walter Bushnell. Other forms of drotaverine such as vials or ampoules will be priced differently, as such, these values are only approximations for the current market situation. Although the prices on the B2B wholesale Pipelinepharma marketplace remain confidential between both B2B parties, the seller may choose to list a desired price to facilitate the online transaction. If so, an ‘Accept’ and ‘Negotiate’ button will be displayed through the online interface, with a ‘Get offer’ button being shown in the absence.