Doxylamine is an antihistamine. It gives relief from symptoms of allergy, hay fever, and the common
cold. It medication works by blocking certain histamine & acetylcholine, substances in the body that causes allergic symptoms. This blocking helps to relieve allergy/cold symptoms such as watery eyes,
runny nose, and sneezing. Doxylamine is used in the short-term treatment of insomnia, a condition in
which the patient feels difficulty falling asleep or staying asleep. It is also used in combination with
decongestants and to relieve sneezing, runny nose, and nasal congestion caused by the common
cold. It is also used as a short-term sedative and hypnotic with other medicines to provide night-time
allergy and cold relief. The preparations containing the analgesics paracetamol and codeine have a
Doxylamine is available under the many different brand names including Unisom.
S. Merrell Company was first marketed in the U.S. in 1956 as Bendectin. However, Doxylamine with
weak hypnotic and calming effects was first reported as early as1949. Doxylamine succinate with
pyridoxine got approval from the USFDA for the first-line treatment of nausea and vomiting of
Forms and Dosage
Doxylamine is sold in the tablet form. In the treatment of Insomnia, Adults and Children over 12 years
old are given a dose of 25 mg orally every evening as needed, this is done 30 minutes before
bedtime. This medicine is not recommended for use in children under 12 years old. In the treatment of
Upper Respiratory Tract Allergy, the standard dose for adults is 50 mg orally every 4-6 hours. The
body tends to develop tolerance when used as hypnotic.
The cost of Doxylamine
In the USA, The consumer has to pay around $13 for a supply of 32 tablets of doxylamine oral 25 mg,
this may vary as depending on the pharmacy. Whereas the supply of 192 tablets costs 21 pounds in
the UK for the 25mg oral tablet.
How does it work?
Doxylamine competitively blocks the histamine receptor, whose actions prevent the actions of
endogenous histamine as well as the release of pro-inflammatory mediators from basophils and mast
cells. It can antagonize the effects of histamine in the large blood vessels, uterus, GI tract, and
bronchial muscles. Doxylamine binds both centrally and peripherally, giving the sedative effects in
helping patients get effective sleeping aid. Doxylamine’s actions also depress labyrinthine function,
block the chemoreceptor trigger zone, and diminishes vestibular stimulation in addition to the
reduction of nausea and vomiting by inhibiting histaminergic signaling to the vomiting center in the
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