Donepezil is a centrally acting reversible acetylcholinesterase inhibitor, belonging to a class of medications called Acetylcholinesterase inhibitors. It improves mental function such as memory, attention, the ability to interact with others, speak, think clearly, and perform regular daily activities by increasing the amount of certain naturally occurring substances in the brain.
Donepezil is used to treat dementia – a brain disorder that affects ability to remember, think clearly, communicate and perform daily activities and may cause changes in mood and personality in people having Alzheimer’s disease where it is used to increase cortical acetylcholine.
Donepezil manufacturers sell this Drug under the Brand name drug Aricept. It is also available as a generic drug. Donepezil comes in two tablet forms namely film coated tablet and disintegrating tablet which can be taken once a day via oral route. It is also available in solution form. This medication can be taken by Adults only and not recommended for pediatric use as a treatment for any medical condition.
The tablet dosage form of Donepezil is available in 5 mg, 10 mg, 23 mg dosage strengths. The 5 mg tablets are white, 10 mg tablets are yellow and 23 mg tablets are reddish in color. The oral disintegrating tablets are available in 5 mg, 10 mg dosage strengths. The 5 mg tablets are white, 10 mg tablets are yellow. Both the tablet forms are engraved with brand name on one side and dosage strength on the other side. The Oral solution form is available in 1 mg/1mL dosage strength.
The recommended storage conditions of Donepezil tablets / orally disintegrating tablets are to store in the original container it came, at a controlled room temperature between 15° C to 30° C (59° F - 86° F).
Wholesale Price of Donepezil
The wholesale price of 30 units of 5 mg Donepezil oral tablet is approximately $ 7.50 with per unit cost comes at $ 0.25. The lowest available wholesale price for the quantity of 100 Donepezil tablets is $ 7.50 - $ 154.68 with per unit costs as low as $ 0.07 - $ 1.55
The per unit cost of 10 mg Donepezil oral tablet is approximately $ 0.25 - $ 2.25, which is available for a price range of $ 7.50 - $ 67.56 for 30 tablets whereas the per unit cost of 23 mg tablet is $ 1.85, which is available for $ 55.40 for a quantity of 100 tablets.
The 5 mg and 10 mg Oral disintegrating tablets are available at a price range of $ 40.89 - $ 48.26 for a set of 30 tablets with per unit ranges between $ 1.46 - $ 1.72
Donepezil - Mechanism of Action
Donepezil inhibits acetylcholinesterase, an enzyme responsible for the destruction of one neurotransmitter, acetylcholine. This leads to increased concentrations of acetylcholine in the brain, and the increased concentrations are believed to be responsible for the improvement seen during treatment with donepezil.
Finding Donepezil Manufacturers and Suppliers
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