DICLOFENAC DIETHYLAMINE
Diclofenac Diethylamine is the key ingredient in most of the Diclofenac preparations.
Topical Diclofenac diethylamine gel is an NSAID. It has proven to be one of the most
effective and well-tolerated NSAIDs in treating acute and chronic musculoskeletal
conditions. When applied topically, it can penetrate the skin barrier to take the drug to reach
joints, muscles, and synovial fluid. Diclofenac is a derivative of phenylacetic acid and an
NSAID. NSAIDs inhibit cyclooxygenase 1 and-2 enzymes responsible for producing
prostaglandins. This medicine is not for sale in the USA.
Prostaglandins increase inflammation and pain signals. So NSAIDs like Diclofenac
Diethylamine is the established first-line therapy in treating acute and chronic pain and
inflammation resulting from a wide range of causes.
Diclofenac Diethylamine is sold under the brand name Voltaren gel among others.
GlaxoSmithKline Consumer Healthcare is one of the current assignees of the Diclofenac
Patent. Ciba-Geigy first patented Diclofenac in 1965. It came into medical use in the USA in
1988.
Dosage and administration
Diclofenac Diethylamine is available as the topical gel and solution, transdermal skin patch
for application externally. This gel is applied to the areas affected by the pain. The
recommended guideline for adults applying the gel for actinic keratosis is applying the gel to
the affected skin area two times a day. In Children, the dose decided by the Doctor. For pain
relief from osteoarthritis of the hands, elbows, or wrists, the recommended dose is the
application of 2 grams to the affected skin areas four times a day, totaling a maximum of 8mg
per day. The upper limit of the dose is 32 grams a day and should not exceed that, even with
several affected joints. In children, the dose must be set by the doctor.
For getting relief from the pain of osteoarthritis of the knees, ankles, or feet using, Adults are
asked to apply 4 grams to the affected skin areas. This is done four times a day using a total
of 16 grams each day. When using the solution, the recommended dose for osteoarthritis of
the knee in adults is 10 drops at a time, on each affected knee, this has to be done four times a
day, totaling 4mg. If using a skin patch, for acute pain in adults, the dose is one patch applied
to the painful area, twice a day
The cost of Diclofenac Diethylamine
In the global wholesale market, the ingredient form of Diclofenac Diethylamine is USD 332
for buying one hundred grams. In India, the cost of a tube with 50mg of this medicine in it
costs USD 1.
How does Diclofenac Diethylamine Work?
Diclofenac blocks thromboxane-prostanoid receptors, affecting the arachidonic acid release and
uptake. It also inhibits lipoxygenase enzymes and activates the nitric oxide-cGMP
antinociceptive pathways. Like all NSAIDs, this also inhibits prostaglandin synthesis by
inhibiting cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) by competing with
them at bindings. However, extensive research proved that Diclofenac can do more than cox
blocking, and includes multimodal and in some uncommon cases, novel mechanisms of
action.
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