This pharmaceutical medicine is known by the brand names Dantrium, Revonto, and Ryanodex. It belongs to the class of drugs known as skeletal muscle relaxants. It is a skeletal muscle relaxant with a direct action that is used to treat fulminant hypermetabolism of skeletal muscle that leads to a malignant hyperthermia crisis. It is administered orally in form of tablets and intravenously in form of injections. The bioavailability of this drug is 70% and is metabolized hepatically, most likely as a result of hepatic microsomal enzymes. It can also be hydrolyzed and then oxidized to generate nitrophenylfuroic acid. The mean biologic half-life following intravenous injection varies between 4 and 8 hours under most experimental settings, but the oral half-life for a 100mg dosage is 8.7 hours. The list of side effects related to this drug includes drowsiness; significant muscular wasting; sluggish or shallow breathing; severe or persistent vomiting or diarrhea; difficulties with vision or speech; and convulsions. It is contraindicated in patients with underlying liver disease, such as cirrhosis, non-alcoholic steatohepatitis, or hepatitis B or C infections. The medicine crosses the placenta easily; nevertheless, no significant side events have been observed in neonates following maternal administration of the drug before birth. This drug has been found in human milk after 3 days of intravenous administration; because of the possibility of serious adverse reactions in breastfed infants, such as respiratory depression and muscle weakness, advise patients that breastfeeding is not recommended during treatment and for 3 days after the last dose.

It inhibits skeletal muscle excitation-contraction coupling via binding to the ryanodine receptor 1 and reducing intracellular calcium concentration.

Oral capsule 25 mg costs about $28 for a pack of 30 and intravenous powder for injection 20 mg costs around $565 for a package of 6 powder for injection.

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