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Dantrolene manufacturers

1 products found

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1 products found

dantrolene

Injection 20 mg

Dossier type
CTD
Dossier status
Ready to file
Country of origin
India
GMP approvals
EU GMP, WHO
Manufacturer #2303

Manufacturer usually replies in 7 days

Dantrolene Manufacturer

This pharmaceutical medicine is known by the brand names Dantrium, Revonto, and Ryanodex. It belongs to the class of drugs known as skeletal muscle relaxants. It is a skeletal muscle relaxant with a direct action that is used to treat fulminant hypermetabolism of skeletal muscle that leads to a malignant hyperthermia crisis. It is administered orally in form of tablets and intravenously in form of injections. The bioavailability of this drug is 70% and is metabolized hepatically, most likely as a result of hepatic microsomal enzymes. It can also be hydrolyzed and then oxidized to generate nitrophenylfuroic acid. The mean biologic half-life following intravenous injection varies between 4 and 8 hours under most experimental settings, but the oral half-life for a 100mg dosage is 8.7 hours. The list of side effects related to this drug includes drowsiness; significant muscular wasting; sluggish or shallow breathing; severe or persistent vomiting or diarrhea; difficulties with vision or speech; and convulsions. It is contraindicated in patients with underlying liver disease, such as cirrhosis, non-alcoholic steatohepatitis, or hepatitis B or C infections. The medicine crosses the placenta easily; nevertheless, no significant side events have been observed in neonates following maternal administration of the drug before birth. This drug has been found in human milk after 3 days of intravenous administration; because of the possibility of serious adverse reactions in breastfed infants, such as respiratory depression and muscle weakness, advise patients that breastfeeding is not recommended during treatment and for 3 days after the last dose.

How does Dantrolene work?

It inhibits skeletal muscle excitation-contraction coupling via binding to the ryanodine receptor 1 and reducing intracellular calcium concentration.

The cost of Dantrolene

Oral capsule 25 mg costs about $28 for a pack of 30 and intravenous powder for injection 20 mg costs around $565 for a package of 6 powder for injection.

Navigating our pharmaceutical marketplace

Being a global B2B pharmaceutical online marketplace, Pipelinepharma is structured to simplify pharmaceutical deals by providing you with an intuitive interface that is easy to engage with. The selection of Dantrolene offerings can be narrowed down with the use of filters and easily weighed against one another according to medication prices and commercial terms. Also, each manufacturer or supplier product description contains essential information about this substance including clinical data, stability zones, countries where this pharmaceutical drug is already registered in. Manufacturers also have special, and delivery terms.

Establishing commercial ties

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Quality assurance

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