Cosyntropin is a medication that stimulates the adrenal glands to release the hormones cortisol and adrenaline. these hormones help the body respond to stress and support many systems of the body including circulation, metabolism, immunity, and the nervous system. It is a synthetic form of a hormone called adrenocorticotropic hormone (ACTH) that is normally produced by the pituitary gland in the brain. It is used as part of a medical test called an ACTH stimulation test that can help the doctor diagnose adrenal gland disorders such as Addison's disease, Cushing syndrome, or hypopituitarism, where the pituitary gland fails to produce the correct hormones. Its rapid effect on the adrenal cortex allows it to be used to perform a 30-minute test of adrenal function.
Cosyntropin is sold under the Brand names, Cortrosyn, Tetracosactide amongst others.
Mylan owns the patent for Cosyntropin. Cosyntropin is marketed by Amphastar Pharms Inc, Mylan Institutional, Sandoz, and Sandoz Inc, and is included in four NDAs.
Forms, dosage, and administration:
Cosyntropin is available as an injection in 2mg vials. For conducting a Rapid Screening Test for Adrenal Function for Adrenocortical insufficiency, the Usual Adult Dose is 0.25 mg, administered through IV or IM route.
The Usual Pediatric Dose for Rapid Screening Test for Adrenal Function Adrenocortical Insufficiency in kids from 0 to 2 years old is 0.125 mg, administered through IV or IM. For kids 3 years or older, the dose is 0.25 mg
The price of Cosyntropin:
In the USA, the consumers have to pay $683 for injectable powder for injection 0.25 mg for a supply of 10 powders for injection. The price of 5ml supply of 60LU cost patients in USD15 in India.
How does it work?
Cosyntropin stimulates steroidogenesis and the release of cortisol, corticosterone, and androgens from the adrenal cortex. Cosyntropin is similar to natural corticotropin in its corticosteroidogenic activity and pharmacologic profile. An injection of 0.25 mg cosyntropin will stimulate to the same extent as 25 Units of natural corticotropin. However, there are additional-adrenal benefits of cosyntropin include melanotropic activity, increased growth hormone secretion, and an adipokinetic effect.
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