CLOPIDOGREL BISULFATE
Clopidogrel bisulfate is an anti-platelet medication. It inhibits platelet aggregation and thus inhibits aspects of blood clotting. It is used to treat patients with acute coronary syndrome, myocardial infarction, peripheral vascular disease and ischemic type strokes. It is effective in preventing strokes, heart attacks, and death in individuals who have had a previous stroke, unstable angina, heart attack or have a peripheral arterial disease. It works by blocking platelets from sticking together and prevents harmful clots. It helps keep blood flowing smoothly in the body. It is a thienopyridine class of drug. It is combined with aspirin than alone in preventing another heart attack.
Clopidogrel bisulfate is sold under the brand name Plavix amongst others.
Bristol-Myers Squibb in collaboration with Sanofi-Aventis developed and manufactured Clopidogrel bisulfate. The US Food and Drug Administration first approved it in 1997.
Forms and dose:
Clopidogrel bisulfate is available as 75 and 300 mg tablets. In the treatment of acute coronary syndrome with a non-ST elevation MI, the initial dose is 300 mg per day. This is followed up by a 75 mg dose per day but for treating ST elevation MIs, the initial and continuing dose is recommended to keep at 75 mg per day.
The price of Clopidogrel bisulfate:
In the USA, consumers have to pay an average price of $30.00 for 30 Tablets of 75mg each. Whereas the price of this medicine is significantly cheaper in the developing world. The price of for the same supply of 30 tablets of 75mg cost only US$4.
How does it work?
Clopidogrel actions prevent blood clots. It does this by irreversibly binding to the receptor on platelets, preventing adenosine diphosphate from activating platelets. As a P2Y12 inhibitors. Eventually, the platelets exposed to clopidogrel’s active metabolite are inhibited for the remainder of their lifespan, which is about 7 to 10 days.
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