Cinnarizine
Cinnarizine treats nausea and vomiting due to motion sickness, chemotherapy, vertigo, or
Ménière's disease and Cogan's syndrome. An antihistamine is also a calcium channel blocker
of the diphenylmethylpiperazine group. It has the rare distinction of having beneficial effect
in the chronic treatment of the vertigo and tinnitus, associated with Meniere's disease.
However, this medication causes drowsiness caused and is thus not or used very rarely
amongst pilots and aircrew who must be dependably alert. British Royal Navy cited it as one
of the most used drugs for seasickness.
Cinnarizine is sold under the brand names such as Neurozine, Sezin and stugeron among
others.
Janssen Pharmaceutica first synthesized it in 1955. Cinnarizine, the nonproprietary name was
given after the cinnamyl substituent on one of the nitrogen atoms. It combines with generic
ending "-rizine" for antihistaminics or cerebral vasodilators.
Cinnarizine is not available in the United States or Canada. However, it is sold in the EU and
the rest of the world.
Dosage and administration
Cinnarizine is available as tablets of 15mg strength. While treating travel sickness, Adults
and children aged 12 years or older are recommended to take two tablets two hours before
travel, followed by one tablet every 8 hours during the journey, when needed. The dose for
Children aged 5 to 11 years is one tablet, taken 2 hours before travel, followed by half a tablet
every 8 hours during the journey when needed. When treating dizziness and sickness caused
by inner ear problems, Adults and children aged 12 years or older are given two tablets to be
taken 3 times a day and in Children aged 5 to 11 years, the dose is one tablet, taken 3 times a
day.
The cost of Cinnarizine
In India, the consumers have pay a average retail price of USD1.5 for 25 tablets of to 25mg
strength. This medicine is not sold in the US and Canada.
How does Cinnarizine Work?
Cinnarizine actions disrupt signal transmission between vestibular apparatus of the inner ear
and hypothalamus, where the vomiting center in the brain resides. It does this by limiting the
activity of the vestibular hair cells which send signals about movement. It is generally
understood that, Vomiting in motion sickness is a compensatory mechanism of the brain,
expressed physiologically.
The confusion in brain whether the individual is moving or standing is reduced by abolishing
the disparity of signal processing between inner ear motion receptors and the visual senses.
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