Cefotaxime is an antibiotic used in the treatment of a number of bacterial infections. Specifically in the
treatment of joint infections, pelvic inflammatory diseases, meningitis, pneumonia, urinary tract
infections, sepsis, gonorrhea, and cellulitis. It is specifically prescribed in the treatment of Lower
respiratory tract infections like pneumonia, which is most commonly caused, by S. pneumonia or
genitourinary system infections - urinary tract infections like E. coli, S. epidermidis, and P. mirabilis
and cervical or urethral gonorrhea. It is also used in the treatment of Gynecologic infections like pelvic
inflammatory disease, endometritis, and pelvic cellulitis and sepsis-like secondary to Streptococcus
spp, S. aureus, E. coli, and Klebsiella spp. It is also used in the treatment of Intra-abdominal
infections like peritonitis, in the treatment of bone and joint infections caused by S. aureus,
Streptococcus spp and CNS infections like meningitis or ventriculitis secondary to N. meningitides, H.
influenzae, S. pneumonia.
Cefotaxime is traded under the brand name Claforan among others.
Takeda chemical industries ltd discovered it in 1976, and Cefotaxime came into commercial use in
1980. It record on efficacy has earned it a place on the World Health Organization's List of Essential
Medicines. It is sold as a generic medication.
Dosage Forms & Strengths
Cefotaxime is given either by injection into a vein or muscle. Its injectable solution is sold in 20mg/mL,
40mg/mL and the powder for injection is for 500mg is sold in 1g, 2g, 10g concentrations. In the
treatment of Gonococcal Urethritis or Cervicitis, the standard recommended dose is 0.5 g IM once,
and in the treatment of Rectal Gonorrhea, the men are recommended a dose of 1 g IM once and
women are prescribed a dose 0.5 g IM once.
In the treatment of Infections Caused by Susceptible Organisms of the Uncomplicated types, the
standard recommended dose is 1 g IV or IM administered every 12 hours and in the treatment of
moderate to severe cases, the dose is 1-2 g IV or IM every 8 hours. In the treatment of More serious
bloodstream infections like septicemia the prescribed dose is 2 g IV given every 6-8 hours and in the
Life-threatening case, 2 g IV every 4 hours but the maximum daily dose cannot exceed 12 g per day.
While preparing Preparation for Surgery, in the treatment of Prophylaxis of surgical infection, the
recommended dose is 1 g IM/IV once 30-90 minutes before the start of the procedure.
The price of Cefotaxime
In the USA, consumers pay $56 for a Cefotaxime injectable powder for injection 1 g is around for a
supply of 25 powder for injection and Cefotaxime Sodium Injection of 4ml, cost around $1.05 in India.
How does it work?
Cefotaxime is a β-lactam antibiotic, meaning it is related to structural components of the drug
molecule itself. β-lactams work by inhibiting bacterial cell wall synthesis by binding to one or more of
the penicillin-binding proteins. The inhibition leads to the final trans-peptidation of peptidoglycan
synthesis in bacterial cell walls, thus inhibiting cell wall biosynthesis. Bacteria lyse due to ongoing
activity eventually in the cell wall autolytic enzymes in the absence of cell wall assembly. β-lactams
are considered to be bactericidal.
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