Cefonicid is a beta-lactamase-resistant broad-spectrum cephalosporin antibiotic that is semi-synthetic. Cefonicid, like other cephalosporins, works against bacteria by inhibiting the formation of bacterial cell walls. Its efficacy against a wide spectrum of Gram-positive and Gram-negative bacteria has been demonstrated in vitro and in vivo. For the treatment of bacterial infections caused by microorganisms that are susceptible to it.
Cefonicid is a cephalosporin of the second generation that is given intravenously or intramuscularly. Its superiority to first-generation cephalosporins against certain enterobacteriaceae, as well as its action against Haemophilus influenzae, including beta-lactamase-producing strains, is similar to that of cefamandole. Its antimicrobial activity against Staphylococcus aureus is comparable to cefoxitin but less effective than cefamandole and first-generation cephalosporins. It is effective against Neisseria gonorrhoeae in vitro, but ineffective against Pseudomonas, Acinetobacter, Serratia, and Bacteroides fragilis.
Cefonicid sodium, a semisynthetic second-generation cephalosporin having antibacterial action, comes in sodium salt form. Cefonicid binds to and inactivates penicillin-binding proteins (PBPs) on the bacterial cell wall's inner membrane. PBPs are enzymes that are involved in the last stages of bacterial cell wall assembly as well as cell wall remodeling during growth and division. PBP inactivation disrupts the cross-linking of peptidoglycan chains, which is required for bacterial cell wall strength and stiffness. As a result, the bacterial cell wall weakens, resulting in cell lysis.
Cefonicid has been given once daily in most clinical trials due to high attainable plasma concentrations and a relatively long half-life. In the treatment of individuals with urinary tract infections, lower respiratory tract infections, and soft tissue and bone infections, it was comparable to cefamandole or cefazolin in terms of efficacy. In the treatment of simple gonorrhea, it has been compared to penicillin. Cefonicid should not be administered in individuals with significant staphylococcal infections, according to the results of a limited study of endocarditis patients. Single preoperative doses of cefonicid appear to provide equal protection against post-surgical infection as several doses of other antibiotics, but further data from studies with larger numbers of patients are needed to validate these findings.
Cefonicid sodium is a broad-spectrum cephalosporin antibiotic that prevents bacteria from forming a cell wall. Antibacterial is the goal. When cefonicid sodium is added both internally and externally to proteoliposomes, it can inhibit the carnitine/carnitine antiport. The presence of various electroactive groups in the molecule can be identified by adsorptive square-wave stripping voltammetry. UV spectroscopy at 265 nm can also be used to detect the chemical in the solution. Escherichia coli, Klebsiella, Citrobacter, Enterobacter, indole-negative Proteus, and Providencia are all susceptible to cefonicid sodium.
Patients who require long-term antibiotic treatment, such as those with osteomyelitis who are being treated as outpatients after a relatively short hospital stay, may benefit from cefonicid's once-daily dosage schedule.
Hives or a rash, swelling of the face, neck, or lips is a common symptom. If you're having problems breathing or wheezing, Some of the negative effects of Cefonicid sodium include severe diarrhea (bloody or watery) and swelling, discomfort, or redness near your IV site.
How does Cefonicid work?
Cefonicid is a beta-lactam antibiotic, similar to penicillin. It inhibits the third and final stage of bacterial cell wall formation by attaching to certain penicillin-binding proteins (PBPs) found inside the bacterial cell wall. Autolysins, which are bacterial cell wall autolytic enzymes, are then used to lyse the cells.
Wholesale Price of Cefonicid
An online search for the wholesale price for sale of Cefonicid for distributors will reveal a wide range of costs. It will vary from store to store depending on your visit and the country of the wholesale market.
Navigating our Pharmaceutical Marketplace
Being a global B2B pharmaceutical online marketplace, Pipelinepharma is structured to simplify pharmaceutical deals by providing you with an intuitive interface that is easy to engage with. The selection of Cefonicid distributors offerings can be narrowed down with the use of filters and easily weighed against one another according to medication prices and commercial terms. The advanced filters help you filter out the countries for these substance manufacturers and this substance Cefonicid suppliers that you are looking for. These also enable you to check the dossier status of this medicine and the GMP approvals of the different variants of Cefonicid. Also, each manufacturer or supplier product description contains essential information about this substance including clinical data, stability zones, countries where Cefonicid is already registered in. Manufacturers also have special, and delivery terms.
Establishing Commercial Ties
If you are a pharmaceutical licensing company or a distributor you can enter into deals or negotiations over these medicine offers with manufacturing companies after completing the free registration process and joining our online marketplace. This helps to ensure that you conclude the pharmaceutical product deal at a reasonable cost and achieve the best cost/benefit ratio for your company while bypassing lengthy sourcing, negotiation, and order process. Once you have finalized a deal, you can look forward to a long-lasting business relationship with the manufacturers Cefonicid suppliers. This way, the marketplace allows you as a distributor to skip the process of shortlisting product manufacturers every time you are looking for in-licensing or distribution deals.
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