Cefazolin is an antibiotic used to treat a number of bacterial infections. Specifically
These infections caused by bacteria affect the skin, bone, joint, genital, blood, heart valve,
respiratory tract, biliary tract, and urinary tract. Doctors also prescribe it to prevent group B
streptococcal disease near the time of delivery. Cefazolin has used the treatment of a wide range
of infections when the susceptible organisms are involved. Cefazolin can also be used during,
before, or after surgeries to prevent post-surgical infections.
Cefazolin also knew as cefazoline and cephazolin, is available under the brand names,
Kefzol and Ancef amongst others.
The first patented for Cefaozlin was filed in 1967 by Braun medical Inc and came into
commercial use in 1971. Given the wide range of applications and its minimal side effects, it
has earned a place on World Health Organization's List of Essential Medicines, the safest and
most effective medicines needed in a health system. Currently, it is being sold as a generic
medication around the world.
Forms and Dosage
Cefazolin is sold as a powder to be mixed with liquid, or as a premixed product, to be
injected intravenously over 30 minutes. Cefazolin injection is also sometimes administered
intramuscularly. Patients are recommended a gap of 6, 8, or 12 hours between doses. The
duration of the treatment will depend on the type of and the severity of the infection. While
treating Moderate-to-Severe Infections, an adult indicated dose is 0.5-1 g IV given every 6-8
hours. For Mild Infections With Gram-Positive Cocci, the patient is administered 250-500 mg
IV every 8 hours. In the treatment of Mild-to-Moderate Cholecystitis, the patient is given 1-2
g IV every 8 hours for up to 7 days and while treating Uncomplicated Urinary Tract Infection
the patients are given 1 g IV every 12 hours.
What is the cost Cefazolin?
The cost for cefazolin injectable powder, 1 g is, $28 for a supply of 25 powder for injections
in the USA, it could vary depending on the store, whereas it costs $.50 in the developing
How does Cefazolin work?
It works by killing bacteria. Cefazolin inhibits cell wall biosynthesis by binding Penicillin
proteins, which stops bacteria growth. These binding proteins are bacterial which catalyze the
last stages of bacteria growth, which is needed to maintain the cell wall. The lack of synthesis
eventually leads the bacteria to continually break down their cell walls. Cefazolin is
bactericidal and as the name suggests, it kills the bacteria rather than inhibiting their growth.
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