Benzydamine
Benzydamine relieves the pain and inflammation associated with a sore throat or mouth
sores caused by radiation therapy. Odontostomatologists treats patients of gingivitis,
stomatitis, glossitis, aphthous ulcers, dental surgery and oral ulceration due to radiation
therapy. It is available as the hydrochloride salt and a locally acting nonsteroidal anti-
inflammatory drug with local anaesthetic and analgesic properties for pain relief and anti-
inflammatory treatment of inflammatory conditions of the mouth and throat.
Otorhinolaryngologists prescribed it in the treatment of glandular fever, pharyngitis, tonsillitis,
post-tonsillectomy, and radiation or intubation mucositis. Benzydamine is also used alone or
as an adjunct to other therapy giving the possibility of increased therapeutic effect with little
risk of interaction.
Benzydamine is sold under the brand name Tantum Verde Difflam and Septabene to name
a few across countries.
Focus Pharmaceuticals Limited is the Marketing Authorisation Holder and the manufacturer
of this medicine based in the UK.
Dose and forms
Benzydamine is a mouth rinse and or gargle and not to be swallowed. It is diluted with equal
amounts of water prior to rinsing or gargling if it causes irritation or burning. For mouth sores,
the cream has to stay in the mouth so that the liquid in contact with the sores for at least 30
seconds before spitting it out. For a sore throat, gargling for 30 seconds is recommended.
The cost of Benzydamine
In the United Kingdom, consumers have to pay 7 pounds for 20 Lozenges 3mg and 8
pounds for Sore Throat Rinse of 200ml. The Spray of 30ml costs 7 pounds and the powder
is sold for 67 pounds for 1% per 100gram. The formulations of this medicine are not sold
widely in the USA.
How does Benzydamine work?
Benzydamine actions effect the local mechanisms of inflammation such as pain, oedema or
granuloma specifically. When applied topically, it demonstrates anti-inflammatory activity
reducing oedema as well as exudate and granuloma formation. It also has analgesic
properties when the source of pain is an inflammatory condition and local anesthetic activity.
Benzydamine poorly affects Hyperthermia indicative of systemic functional involvement.
Furthermore, Benzydamine is a weak inhibitor of the prostaglandin synthesis. It exerts its
effects mostly through inhibition of the synthesis of proinflammatory cytokines including
tumour necrosis factor-alpha without significantly affecting other pro-inflammatory or anti-
inflammatory cytokines.. The local anesthetic activity of the compound has been related to
an interaction with cationic channels.