What does it do? Urokinase is a naturally occurring enzyme in humans and other animals, which helps, dissolve the blood clots in their bodies. Urokinase is encoded in humans by a gene, which stands for "plasminogen activator, Urokinase". It is an enabler of a number of biological functions. Processes that naturally prevent blood clots from occurring or the normal breakdown of clots, in the development of the embryo, in the development and maintenance of our multicellular organisms, helps the body renovate its tissue, ovulation, and wound healing. It naturally occurs in human urine or kidney cell culture. One of the application is the disruption of the clotting process and breaking down of the blood clots lodged in patients with pulmonary embolism. Given its nature, it is used widely in the treatment of Deep vein thrombosis, heart attack, pulmonary embolism, and thrombotic disorder or vascular obstruction caused by catheters. Urokinase manufactures and suppliers market it under several brand names, including the brand name Kinlytic that FDA approved in 2007. So far, it has been used to treat 4 million patients suffering from pulmonary embolisms and clots caused by intravenous catheters. This drug has an established reputation for efficacy and safety. McFarlane and Pilling discovered the human Urokinase protein in 1947, but they did not name it. It was originally isolated from human urine in 1952, but it is also found in the blood and in the extracellular matrix of our tissue. Dosage: Urokinase is sold in the form of Injection, powder, lyophilized, for solution In this treatment of pulmonary embolism, the pulmonologist will start with an Initial dose of 4400 international units/kg IV at a rate of 90 mL/hr over 10 minutes and the following Maintenance dose is administered 4400 international units/kg/hr IV at a rate of 15 mL for 12 hours. In the treatment of Deep Vein Thrombosis, The normal regimen consists of 4400 U/kg as an IV bolus followed by a maintenance drip of 4,400 U/kg/hr for 1-3 days. The patient is monitored for the thrombus resolution. There are also different types of doses depending on the type of clot it has to resolve. The wholesale cost of Urokinase In the USA, the cost of 1mg of Urokinase vial is up to USD1195, and the enzyme extract costs USD 112 per gram in 2019. The price of Urokinase varies widely around the world, some countries have reported prices as low as USD 56, to up to USD 500 in the developing world. How does it work? Urokinase, a serine protease found normally in the human body. Manufacturers use novel biotechnology to make it through a cell culture process. It clears the clots related blockages using the protein cleaving enzyme leading to the breakdown of a major structural component of our body that forms the blood clots. Finding Urokinase Manufacturers and Suppliers: The process of finding trusted Urokinase manufacturers and Urokinase suppliers can be made simpler, quicker and more accessible by using Pipelinepharma's online platform, a B2B marketplace that lets you finalize the deals of pharmaceutical products in a matter of a few clicks. Also, it is an easy to use online platform to grow your business opportunities. The robust search engine makes it convenient to search for manufacturers and suppliers of Urokinase. The search can be further refined with industry-specific filters such as dossier type, country of origin, GMP approvals, and search criteria for Wholesaler, etc. helping to get in contact with the preferred manufacturer and supplier readily. International makers: Abbott Labelers of Urokinase: Microbix, ImaRx Therapeutics, Inc. India: in india there are 33 brands which have urokinase in them Some of the indian makers: Taj pharma, Dabur, Samarth, VHB, life medicare and biotech, unichem, Aristo, TTk healthcare and Cadilla to name a few