What does it do?
Urokinase is a naturally occurring enzyme in humans and other animals, which helps,
dissolve the blood clots in their bodies. Urokinase is encoded in humans by a gene, which
stands for "plasminogen activator, Urokinase". It is an enabler of a number of biological
functions. Processes that naturally prevent blood clots from occurring or the normal
breakdown of clots, in the development of the embryo, in the development and
maintenance of our multicellular organisms, helps the body renovate its tissue, ovulation,
and wound healing. It naturally occurs in human urine or kidney cell culture. One of the
application is the disruption of the clotting process and breaking down of the blood clots
lodged in patients with pulmonary embolism.
Given its nature, it is used widely in the treatment of Deep vein thrombosis, heart attack,
pulmonary embolism, and thrombotic disorder or vascular obstruction caused by catheters.
Urokinase manufactures and suppliers market it under several brand names, including the
brand name Kinlytic that FDA approved in 2007. So far, it has been used to treat 4 million
patients suffering from pulmonary embolisms and clots caused by intravenous catheters.
This drug has an established reputation for efficacy and safety.
McFarlane and Pilling discovered the human Urokinase protein in 1947, but they did not
name it. It was originally isolated from human urine in 1952, but it is also found in the blood
and in the extracellular matrix of our tissue.
Urokinase is sold in the form of Injection, powder, lyophilized, for solution
In this treatment of pulmonary embolism, the pulmonologist will start with an Initial dose of
4400 international units/kg IV at a rate of 90 mL/hr over 10 minutes and the following
Maintenance dose is administered 4400 international units/kg/hr IV at a rate of 15 mL for 12
In the treatment of Deep Vein Thrombosis, The normal regimen consists of 4400 U/kg as an
IV bolus followed by a maintenance drip of 4,400 U/kg/hr for 1-3 days. The patient is
monitored for the thrombus resolution. There are also different types of doses depending
on the type of clot it has to resolve.
The wholesale cost of Urokinase
In the USA, the cost of 1mg of Urokinase vial is up to USD1195, and the enzyme extract costs
USD 112 per gram in 2019. The price of Urokinase varies widely around the world, some
countries have reported prices as low as USD 56, to up to USD 500 in the developing world.
How does it work?
Urokinase, a serine protease found normally in the human body. Manufacturers use novel
biotechnology to make it through a cell culture process. It clears the clots related blockages
using the protein cleaving enzyme leading to the breakdown of a major structural
component of our body that forms the blood clots.
Finding Urokinase Manufacturers and Suppliers:
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International makers: Abbott
Labelers of Urokinase:
Microbix, ImaRx Therapeutics, Inc.
India: in india there are 33 brands which have urokinase in them
Some of the indian makers:
Taj pharma, Dabur, Samarth, VHB, life medicare and biotech, unichem, Aristo, TTk
healthcare and Cadilla to name a few