Triptorelin

Triptorelin is a medication used to treat prostate cancer as part of androgen deprivation therapy (ADT). Triptorelin acts as an agonist analog of Gonadotropin-releasing hormone. The resulting outcome is a reversible repressing of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). As a decapeptide and an agonist of gonadotropin-releasing hormone, it is used as an acetate or pamoate salt. Some of the primary conditions for this medicine is prescribed are endometriosis, reduction of fibroids, prostatic cancer, and male hypersexuality with severe sexual deviation. In the United Kingdom, Triptorelin is part of the hormone replacement therapy because it suppresses testosterone or estrogen levels in transgender people. It is used in chemically castrating sex offenders or suppressing their urges. Triptorelin is sold under the brand names Decapeptyl and Gonapeptyl among others. Abbot labs first patented Triptorelin in 1975 and it was approved for medical use in 1986 by the USFDA.

Dosage Forms & Strengths

Triptorelin is sold as a lyophilized powder for reconstitution. The standard adult dose for the treatment of Advanced Prostate Cancer is 22.5 mg, by intramuscular injection given every 6 months or 11.25 mg, given every 3 months or 3.75 mg given every month. In preventing Precocious Puberty, the Usual Pediatric Dose for kids 2 years and older is 22.5 mg to be administered every 4 months.

The price of Triptorelin

In the USA, consumers have to pay around $859 for a supply of 1 intramuscular powder for injection of 3.75 mg every month. The medicine is significantly cheaper in the developing world with the same supply as the USA, for 1 injection of 3.75 mg, each month cost around $85-$90.

How does it work?

Triptorelin is a Gonadorelin analogue. It works by binding itself to receptors in the pituitary gland and stimulates the secretion of gonadotrophins. The resulting actions start the initial phase of LH and FSH stimulation, before down-regulation of the gonadotrophin-releasing hormone receptors. All this eventually results in a reduction in the release of gonadotrophins in the long term, which in turn leads to the inhibition of androgen and oestrogen production.

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