Tramadol is a synthetic opioid analgesic and serotonin/norepinephrine reuptake inhibitor. Tramadol is part of the opioid class drug and is used to treat mild to severe pain. Tramadol medicine is effective for both general and nerve-related pain.

In 1963, Grünenthal GmbH developed Tramadol. In 1977, the West German company launched it under the trade name Trama. The UK approved Tramadol medical use in the mid-1990s.In the US, the FDA approved the medical use of Tramadol in 1995, but the extended-release versions of the drug will only be approved years later, in 2005.

Tramadol is marketed as both generic and trade name medications. In the US, the most known Tramadol brand names are Ultram, ConZip, Ultram ER. Tramadol is among the most popular pharmaceutical opioids, accounting for over 19 million prescriptions yearly in the U.S. alone.

The manufacturers of Tramadol include CSL Limited, Grunenthal GmbH, Mundipharma, Hexal AG, Purdue Pharma Products Lp, Victory Pharma Inc, Actavis Elizabeth Llc, Alphapharm pty Ltd, Amneal Pharmaceuticals Llc, Apotex Inc, Mallinckrodt Inc, Mutual Pharmaceutical Co Inc, Mylan Pharmaceuticals Inc, Sandoz Inc, Teva Pharmaceuticals USA Inc, and Watson Laboratories among others.

Notable Tramadol suppliers are Sanofi-Aventis, Novartis, Janssen, A.Menarini, and KRKA.

The drug is primarily marketed as 50 mg, 100 mg immediate-release tablets as well as 100 mg, 200 mg, 300 mg extended-release Tramadol tablets, but also in the forms of 100 mg, 150 mg, 200 mg, 300 mg extended-release capsules, oral drops, injectable solutions, 50 mg ODT tablets, and lyophilized powders. Tramadol is available as a standalone medication and as an ingredient in combination drug formulations (along with paracetamol, dexketoprofen, or domperidone).

Tramadol patent has expired and many manufacturers are producing this medication on a high scale, for those reasons, Tramadol prices are quite low. Tramadol costs depend on the country it is sold in and the health policies of the country. Due to the side effects and dependency risks associated with opioid drugs, the sale of Tramadol is prohibited in certain countries. Also, other countries may have national laws that limit the export, import, distribution, or commercialization of Tramadol.

In the US, a 50 mg Tramadol tablet costs from $0.23 to $1.21 per unit. For a 100 mg extended-release tablet, Tramadol costs from $1.46 to 1.73 per unit, for a 200 mg extended-release tablet, Tramadol costs from $2.01 to $2.69 per tablet, and for a 300 mg extended-release tablet, Tramadol costs from $2.41 to $3.45 per unit.

As Tramadol is a globally found drug, on the internet you can encounter fraudulent websites that will want to sell Tramadol with some risks for you and your clients. By using Pipelinepharma B2B marketplace, you avoid time-consuming sourcing and you directly find qualified sellers of Tramadol that have been through quality control procedures to assure they were qualified partners. On the online platform, Tramadol is mostly available from the EU, India, Bangladesh, Australia, Mexico, Thailand, Switzerland, Guatemala, Indonesia, Argentina, and South Korea. Thanks to the intuitive online marketplace, you will find Tramadol and many other drugs quickly and efficiently. Placing an order or an inquiry has never been easier than with Pipelinepharma. Let us connect you with Tramadol manufacturers wherever they are in the world. Not only is this marketplace good news for distributors and other buyers, but wholesale sellers and manufacturers benefit as well. They can register and list an unlimited number of pharmaceutical products free of charge.

To relieve pain, an adult (over 17 years old) patient should take 50 mg to 100 mg of Tramadol every four to six hours as needed. The maximum Tramadol dose is 400 mg per day. To relieve chronic pain, an adult patient (over 18 years old) should take 100 mg extended-release Tramadol once a day. The maximum dose is 300 mg of Tramadol per day.

If patients desire to switch from another opioid treatment, it is recommended to discontinue all other around the clock opioid drugs before initiating therapy. The initial dose should be 100 mg extended-release of Tramadol once a day. The maximum dose is 300 mg of Tramadol per day.

Taking Tramadol can cause some side effects, the most common ones are constipation, itchiness, joint pains, dry mouth, sweating, and nausea. Tramadol can also cause more serious side effects, such as seizures, increased risk of serotonin syndrome, decreased alertness, and drug addiction.

Tramadol is not recommended to pregnant women either to patients who are at risk of suicide. Tramadol must be stored at room temperature, away from heat, moisture, and direct light, it should remain in the container it comes in. Tramadol, as an opioid drug, exposes patients and other users to the risks of opioid addiction, abuse, and misuse, which can lead to overdose and death. Before stopping abruptly Tramadol treatment, it is imperative to talk to a doctor and to slowly reduce the dosage, abrupt discontinuation in patients who are physically dependent on opioids could cause serious withdrawal symptoms, uncontrolled pain, attempts to find other opioids, and suicide.