Thalidomide is a medication used to treat multiple myeloma, graft-versus-host disease, and certain skin diseases, such as leprosy. Initially unsuccessfully used to treat morning sickness in pregnant women, thalidomide was withdrawn from the market and later repurposed as a cancer medication. It is marketed as 50mg-200 mg thalidomide capsules. Approved as a cancer treatment by the FDA in 1998, the drug is currently marketed in numerous countries worldwide, including but not limited to Australia, India, Taiwan, across the EU, and the U.S. It is also one of the medications that are contained in the World Health Organization's List of Essential Medicines that contains the safest and most effective drugs recommended for a health system. The largest manufacturer and supplier in the thalidomide medication market is Celgene, which markets the drug under the trade name Thalomid. Other notable Thalidomide manufacturers include Dr. Reddy’s and Mylan. Thalidomide is available as a trading name as well as a generic medication. Buyers are advised that online sellers may attempt to market fraudulent versions of the generic drug, whereas Pipeline Pharma, through its pre-auditing and quality control procedures ensures that only verified Thalidomide manufacturers and wholesalers enter our online marketplace, offering you a risk-free B2B pharmaceutical sales platform. Expectant mothers or may get pregnant while on thalidomide should avoid taking it. Even a single dose of thalidomide given during pregnancy can result in serious birth abnormalities (physical disorders present at birth in the infant) or the unborn baby's death. The Food and Drug Administration (FDA) has established a program called Thalidomide REMS® (previously known as the System for Thalidomide Education and Prescribing Safety [S.T.E.P.S.®) to ensure that pregnant women do not consume drugs or become impregnated while taking it. To receive thalidomide, all people who have prescribed it, including men and women who are unable to become pregnant, must first register with Thalidomide REMS®, then obtain a thalidomide prescription from a doctor who is also registered with Thalidomide REMS®, and have the prescription filled at a pharmacy that is also registered with Thalidomide REMS®.
How Does Thalidomide Work?
The mode of action in people with erythema nodosum leprosum (ENL) is unknown. The immunologic impacts of this chemical agent, according to available data from in vitro studies and preliminary clinical trials, can vary significantly depending on the situation, but they may be related to the suppression of excessive tumor necrosis factor-alpha (TNF-a) generation and flip of selected cell exterior adhesion molecules in monocytes migration. The use of thalidomide, for instance, has been demonstrated to lower circulating levels of Tumor necrosis factor in individuals with ENL, but it has also been seen to raise plasma Tumor necrosis factor levels in HIV-positive patients. Thalidomide is an immunostimulatory drug with a wide range of activities that has yet to be fully understood. Thalidomide is an enantiomers substance. It contains equal levels of both left and right-handed isomers: one is beneficial against stomach pain, while the other is mutagenic. In vivo, the mixtures are transformed into one another. That is, if a person is given either D-thalidomide or L-thalidomide, the serum will include both isomers. As a result, giving only one homolog to people will not avoid the teratogenic impact.
The Cost of Thalidomide
The cost per monthly treatment amount with thalidomide in the U.S. is approximately 6,000 – 9,500 USD as of 2019, depending on concentration. Meanwhile, the retail price of the same amount of 50mg thalidomide tablets ordered in the EU is around 370 EUR. This medicine can be purchased at a variety of prices from a variety of Thalidomide manufacturers and dealers. Prices are solely valid for cash-paying customers and do not apply to insurance policies. Pharmaceutical corporations generally support patient assistance programs. Prices may differ on different drugstores.
Navigating our Pharmaceutical Marketplace
Being a global B2B pharmaceutical online marketplace, Pipelinepharma is structured to simplify pharmaceutical deals by providing you with an intuitive interface that is easy to engage with. The selection of thalidomide offerings can be narrowed down with the use of filters and easily weighed against one another according to medication prices and commercial terms. The advanced filters help you filter out the countries for these substance manufacturers and these Thalidomide suppliers that you are looking for. These also enable you to check the dossier status of this medicine and the GMP approvals of the different variants of Thalidomide. Also, each manufacturer or supplier product description contains essential information about this substance including clinical data, stability zones, countries where Thalidomide is already registered in. Manufacturers also have special, and delivery terms.
Establishing Commercial Ties
If you are a pharmaceutical licensing company or a distributor you can enter into deals or negotiations over these medicine offers with manufacturing companies after completing the free registration process and joining our online marketplace. This helps to ensure that you conclude the pharmaceutical deal at a reasonable cost and achieve the best cost/benefit ratio for your company while bypassing lengthy sourcing, negotiation, and ordering process. Once you have finalized a deal, you can look forward to a long-lasting business relationship with the manufacturers and Thalidomide suppliers. This way, the marketplace allows you as a distributor to skip the process of shortlisting product manufacturers every time you are looking for in-licensing or distribution deals.
To keep up to the quality standards other than Good Manufacturing Practice approvals that this medicine manufacturers list has, we qualify their companies before they are onboarded on the platform. This allows us to screen Thalidomide for the quality of the pharmaceutical products’ dossiers and protect against the risk of possible malpractices.