Terlipressin

Terlipressin is an analogue of vasopressin. It is used as a vasoactive drug in the management of Low Blood Pressure or hypotension. It has been found effective in patients whose other norepinephrine failed in the management of low blood pressure. It is also used in the treatment of bleeding esophageal varices and help prevent urination. Terlipressin is sold under the brand name Glycylpressin Ferring, Glypressin Biopas, and Ferring to name a few. Cyon Therapautics Inc filed the first patents for this medicine in but it was approved. Terlipressin is not sold available in the United States, or Canada, but it is available in New Zealand, Australia, Europe, India, Pakistan & UAE.

Forms and dose:

Terlipressin is available as an acetate, in 0.12 mg for ml solution, for an injection. For treating adults, initial dose starts at 1 to 2 mg of terlipressin acetate, that is also equivalent to 8.5 to 17 ml of solution. It is administered by intravenous injection over a period of time. The dose can vary by body weight with people less than 50kgs get 1mg dose and those exceeding 70kgs getting a dose of 2mg. After the initial dose, it is decreased to 1 mg acetate, given every 4 to 6 hours. The patients feels better after about 3 days of treatment.

The price of Terlipressin:

In the USA, the consumers have to pay USD 113 for a 10 vials fo 1ml solution. The 5mg vials costs USD 60, to 10mg cost USD84 and the 50Mg costs USD 204. The price of this medicine is significantly lower is the developing part of the world. India, the same injection of 1ml csots only about USD18.

How does it work?

Terlipressin is a naturally occurring hormone present in the body, known as antidiuretic hormone or vasopressin. This hormone has two main effects in the body namely causing narrowing of blood vessels called vasoconstriction that limits blood flow to a particular area of the body. Its actions also make kidney to retain water in the body, helping prevent excessive loss of water in the urine.

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