Generics 4

Originals

Biosimilars

Medical devices

Nutraceuticals

Filters

Sodium phenylbutyrate manufacturers

4 products found

Filters

4 products found

sodium phenylbutyrate

Tablets 500mg

Dossier type
EU CTD
Dossier status
Ready to file
Country of origin
European Union
GMP approvals
EU GMP
Unavailable markets
United Kingdom
Manufacturer #13160
It is an international biopharmaceutical company focused on rare diseases. They are dedicated to providing access to innovative treatments that transform the lives of people with rare diseases. They focus on two therapeutic areas – hematology and immunology – and also have a portfolio of specialty care products. They have in-house capabilities that stretch from late-stage R&D, biologics manufacturing and supply, to patient access and distribution.

Manufacturer usually replies in 16 days

sodium phenylbutyrate

Oral powder 250g

Dossier type
US CTD
Dossier status
Ready to file
Country of origin
United States
GMP approvals
FDA
Manufacturer #19592

Manufacturer usually replies in 2 days

sodium phenylbutyrate

Tablets 500 mg

Dossier type
CTD
Dossier status
Ready to file
Country of origin
Taiwan
GMP approvals
Taiwan
Manufacturer #20539
It was established in the 2010s. The main business is the development, manufacture, and sales of niche drugs and special health foods, as well as the import and export of pharmaceutical products. Currently, in addition to actively developing its brand of drugs and special health food, it also accepts customer entrusted development and OEM services. They aim to provide the best medicines and special health foods that meet the needs of patients, continues to introduce the latest equipment and operating systems, are committed to improving the quality and value of products, and hopes to create the best interests of the industry, patients, and partners.

Manufacturer usually replies in 9 days

sodium phenylbutyrate

Tablets 500 mg

Dossier type
CTD
Dossier status
Under development
Country of origin
India
GMP approvals
WHO
Manufacturer #30444

Manufacturer usually replies in 4 days

Sodium phenylbutyrate

Sodium phenylbutyrate is a salt of an aromatic fatty acid, 4-phenylbutyrate, or 4-phenyl butyric acid. It is used to treat urea cycle disorders, genetic diseases in which nitrogen waste builds up in the blood plasma causes a state called hyperammonemia due to deficiencies in the enzymes. These enzymes include carbamoyl phosphate synthetase I, ornithine transcarbamylase, or argininosuccinic acid synthetase. If uncontrolled, this leads to mental retardation and early death. It works through its metabolites, which offer an alternative pathway to the urea cycle, which facilitates excess nitrogen excretion. Patients with this condition could need the treatment for a lifetime. Sodium phenylbutyrate inhibits histone deacetylase and chaperone, leading research into it for the treatment of cancers and cystic fibrosis, caused by protein misfolding. Sodium phenylbutyrate is sold under the brand names Buphenyl, Ammonaps, triButyrate among others. Hyperion Therapeutics, inc introduced the above treatment was in the 1990s and approved by the U.S. Food and Drugs Administration (FDA) in 1996. It is an orphan drug, marketed by Upcycled Pharma by Swedish Orphan International, and by Fyrlklövern Scandinavia.

Dosage and administration

Sodium phenylbutyrate is administered orally or by nasogastric intubation as ingested as tablet or powder and tastes very salty and bitter. Sodium phenylbutyrate can be given to children above 20 kg and for adults. The usual daily dose of tablets and Powder for patients with urea cycle disorders is 450 to 600 mg per kg per day in patients weighing less than 20 kg and/or 9.9 to13.0 g per m2 per day in larger or adult patients. Both the tablets and powder are to be taken in equally divided amounts with meal or feeding, three to six times per day. The Powder for oral use given via mouth, food, or nasogastric tube only after mixing with solid or liquid food and consumed immediately. Sodium phenylbutyrate is very soluble in water at the rate of 5 grams per 10 mL. the powder, when dissolved in water, stays stable for one week at room temperature or if refrigerated.

The price of Price sodium phenylbutyrate

In Europe, the consumers have to pay €1,235 for a supply of 250 tablets of 500mg. in the USA, the oral powder for reconstitution (0.94 g/g) costs around $3,938 for a supply of 250 grams.

How does it work?

Sodium phenylbutyrate is a pro-drug, which turns into active compound phenylacetate. Phenylacetate conjugates with glutamine through an acetylation reaction to form the product phenylacetylglutamine. This is excreted by the kidneys, thus providing an alternative a mechanism for waste nitrogen excretion.

Finding Sodium phenylbutyrate Manufacturers and Suppliers:

The process of finding trusted Sodium phenylbutyrate manufacturers and Sodium phenylbutyrate suppliers can be made quicker and more accessible by using Pipelinepharma's the online platform, a B2B marketplace that lets you finalize the deals of pharmaceutical products in a matter of a few clicks. In addition, it is easy to use an online platform to grow your business opportunities. The robust search engine makes it convenient to search for manufacturers and suppliers of Sodium phenylbutyrate. The search can be further refined with industry-specific filters such as dossier type, country of origin, GMP approvals, and search criteria for Wholesaler, etc. helping to get in contact with the preferred manufacturer and supplier readily.