SODIUM AESCINATE
Sodium aescinate is a vital salt of sodium escin. It is extracted from Horse chestnut seeds. Sodium Aescinate is also used for the treatment of acute lung injury, acute respiratory distress syndrome and other conditions. Sodium aescinate treats cerebral edema, venous reflux disease and as a vasoactive drug. Topical application of SA helps wounds heal significantly faster as it deposits compact collagen and newly regenerated epithelial layer. In wounds or Injuries could be contusions, sprains, bruises, haematoma formation, tendinitis, vertebral pain syndrome, intervertebral disk, nuchal pain, lumbago, sciatica, superficial phlebitis, and varicose veins.
Sodium aescinate is sold under the brand names like Escin, sodium salt, Na-aescinat, Aescin sodium salt, among others. However, this medicine is now made by several local manufacturers and suppliers around the world.
Riedel De Haen Ag was assigned the first USA patent for obtaining pure chestnutsaponin in the early 1950s. Lek Tovarna Farmacevtskih filed the first patent for isolating aescin from fruits of the horse-chestnut tree in 1976. However, after the expiry of this patent, the early 2000s, several other companies have filed a patent for other uses such as use in vaccines by GSK and other companies.
Forms and Dosage:
Sodium Aescinate is sold as both tablet and a gel. To decrease localised swelling following injuries, the recommended dose is 20 mg. the initial dose for Adults and Adolescents is 2 tablets 3 times daily, whereas in In milder cases or as a maintenance dose, 1 tab of 20 mg is taken three times a day. Kids between 7 and 14 years are given 1 tab of 20mg, 2 or 3 times a day. The normal course of treatment lasts for 2-3 months.
The price of Sodium Aescinate:
In the wholesale market, from China, resellers can buy 5mg injections for the price as low as US$0.1an injection. In Malaysia, the consumer has to an average retail price of US$2.35 for a supply of 50 tablets of 20mg. In India, this medicine is sold for USD2.2 for the supply of 40 tablets of 20mg and USD1.6 for 5mg injection. This medicine is not sold in pharmacies in the USA and Europe.
How does Sodium Aescinate work?
Sodium Aescinate actions change the permeability of the affected capillary walls. IT also raises capillary resistance, inhibiting inflammatory processes and improving microcirculation. Sodium aescinate has anti-inflammatory, immunity enhancing, and antioxidant properties. As a result, it is effectively able to control and improve wound healing. It has antiangiogenic effects result in the initiation of angiogenesis and inhibited proliferation of endothelial cell and decreases the secretion of VEGF.
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