Sevelamer
Sevelamer is a drug used to treat a high level of phosphates in patients suffering from chronic
kidney disease, specifically amongst patients who are on dialysis due to chronic kidney
diseases. It is called a phosphate binder when taken with meals; it binds to dietary phosphate
and prevents its absorption. Normally functioning kidneys are designed to remove extra
phosphorus in your blood, but in patients with chronic kidney disease, the kidneys cannot
remove phosphorus enough so the resulting high phosphorus levels cause damages to the
body. In patients with CKD (Chronic Kidney Disease), it helps to reduce bad cholesterol and
triglycerides and increases the amount of good cholesterol (HDL).
Phosphate in the blood is removed in dialysis. However, even this may not bring down
phosphate levels to the desired balance. It is vital to have lower phosphate levels, a decrease
in blood phosphate helps maintain strong bones, acts as a preventer of the unsafe buildup of
minerals in the body, thus decreasing the probability of heart disease and strokes resulting
from high phosphate levels.
Sevelamer and is currently marketed under the brand name Renagal amongst others.
In 1998, GelTex Pharmaceuticals invented Sevelamer and got it approved by FA. Sevelamer
is marketed by Sanofi under the trade names Renagel (sevelamer hydrochloride) and Renvela
(sevelamer carbonate).
Forms and Dosage
Sevelamer is sold as a tablet and as a powder for the suspension to take by mouth. The tablet
is sold in the strengths of 400mg and 800mg and in the powder packet for oral suspension,
the strengths are 800mg and b 2400mg. in the treatment of hyperphosphataemia, in adult
patients are given a standard dose of 800mg film-coated tablets.
The cost of Sevelamer
In the USA, the price of Sevelamer oral powder is around $724 for a supply of 90 days,
depending on the pharmacy, insurance, and the programs that the patient is on. Whereas the
same medication can cost only 50 pounds in Britain due to extensive work in the EU to bring
down the price of this medication. In the developing world too, the generic version of this
medication and in the USA too, in the discount pharmacies, the drug is sold for a significant
discount.
How does Sevelamer work?
Sevelamer is a non-absorbable phosphate-binding crosslinked polymer, free of metal and
calcium and it has multiple amines separated by one carbon from the polymer, protonated in
the stomach. The pronates bind negatively charged ions like dietary phosphate in the
intestine. Sevelamer lowers the phosphorus concentration in the serum by binding phosphate
in the gastrointestinal tract and decreasing absorption.
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example.
https://en.wikipedia.org/wiki/Sevelamer
https://medlineplus.gov/druginfo/meds/a601248.html
https://reference.medscape.com/drug/renagel-renvela-sevelamer-343208
https://www.medicines.org.uk/emc/product/3681/smpc
https://www.drugs.com/mtm/sevelamer.html