Drug Name: Sevelamer Carbonate Chemical formulation: C7H14ClNO4 Active ingredient: Sevelamer Carbonate Common/generic brand name: Sevelamer Carbonate Approved by FDA or not: FDA approved Commonly marketed in: India, Australia, Canada, China, European Union, the United Kingdom, and the United States. Density: Sevelamer is available in 400mg and 800mg tablet dosages, as well as 800mg and 2400mg powder packets for oral suspension. The suggested Initial Amount for patients with chronic kidney disease on dialysis who are not using phosphate binder is 1600 mg every 8 hours; however, this dose can vary depending on the concentration as determined by the doctor. The substitute dose for people transitioning from calcium acetate is 800 mg for 667 mg Ca-acetate, 1600 mg for 1334 mg Ca-acetate, or 2400 mg for 2001 mg Ca-acetate.

Individuals on dialysis who have chronic kidney disease are given Sevelamer Carbonate to manage high phosphorus levels in their blood. Phosphate binder Sevelamer attaches to dietary phosphate and inhibits it from being absorbed. Polyallylamine is conjugated with epichlorohydrin to form Sevelamer Carbonate. In the gut, several amine groups are partially protonated and bind with phosphate ions via hydrogen and ionic bonding, lowering serum uric acid considerably. It, on the other hand, has no negative consequences and has a number of positive ones, such as lowering hyperuricemia, uric acid nephrolithiasis, and arthritis.

Sevelamer Carbonate is available in tablets and powder.

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Sevelamer is a non-absorbed bound crosslinked polymer with several amines spaced from the polymer backbone with one carbon. In the gut, their protonated forms establish ionic and hydrogen bonds with phosphate molecules. Its activities bind phosphate in the gastrointestinal tract, reducing absorption. It reduces the amount of phosphate in the blood. Its effects cause advanced glycation end products to be sequestered in the gut, blocking their absorption into the bloodstream. These chemicals generate oxidative stress, which damages the beta cells in the pancreas that make insulin.

It is possible to experience headaches, diarrhea, stomach discomfort, nausea, puking, congestion, gas, or constipation. Notify the doctor or pharmacist right away if any of these side effects remain or intensify.

If anyone suffers any significant side effects, such as issues with your dialysis access sites, severe nausea to urinate, symptoms of abdomen bleeding or ulcers (like black/bloody feces, puke that looks like ground coffee, abdomen pain, disorientation).

This medicine seldom causes a severe allergic reaction. However, if anyone detects any symptoms of a major allergic response, such as redness, itchiness, extreme dizziness, or problems breathing, seek medical treatment right once.

The usage of the tablet formulation of sevelamer has been linked to cases of dysphagia and esophageal tablet retention, with some patients requiring hospitalization and intervention. In patients with a history of swallowing problems, sevelamer suspension may be used.

Sevelamer carbonate is not taken systemically after oral treatment, therefore it is unlikely that prenatal exposure to the drug will occur. Considerations in Clinical Practice, in pregnant women, sevelamer carbonate may lower serum levels of fat-soluble vitamins and folic acid. Sevelamer Carbonate is not concentrated by the mother after oral treatment, and it is unlikely that the kid will be exposed to Sevelamer Carbonate through breastfeeding. Considerations in Clinical Practice In pregnant women, sevelamer carbonate may lower serum concentrations of fat-soluble vitamins and folic acid.