Drug Name: Rifampicin Chemical formulation: Active ingredient: Rifampicin, sodium sulfoxylate and sodium hydroxide Common/generic brand name: Rifampicin Approved by FDA or not: FDA approved Commonly marketed in: Ukraine, EU, Colombian, Jordan, Korea, Egypt, China, and India Density: In case of tuberculosis: 10 mg/kg PO daily or 10 mg/kg PO twice week (directly observed therapy [DOT]); maximum of 600 mg/day for adult. 10-20 mg/kg IV/PO or 10-20 mg/kg PO biweekly (DOT); maximum dose is 600 mg/day for paediatrics.

Rifampicin, also known as Rifampin, is a medication used to treat bacterial infections in patients. Rifampicin, whether generic or branded, can be used orally or injected in combination with other antibiotics. Rifampicin is an antibiotic that is used to cure mycobacterial illnesses such as Mycobacterium avium complex, leprosy, and hidden or active tuberculosis in conjunction with other antibacterials.

Rifampicin is available in both capsules of 150 mg and 300 mg alongside 600 mg injectable powder.

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It is an antibiotic medicine that belongs to the class of drugs known as antimicrobials. Its main aim is to prevent and cure bacterial infections, as well as to treat or avoid tuberculosis. Patients with Legionnaires' disease, leprosy, Mycobacterium avium complex, and other disorders can also benefit from this prescription drug. When aiming to prevent meningococcal illness and Haemophilus influenzae type b, though, the medicine will be given as a stand-alone medicine with no other medications.

This medication may induce stomach pains, heartburn, nausea, menstruation irregularities, headaches, drowsiness, or dizziness. Notify your doctor right away if any of these side effects continue or intensify. This medicine may produce color changes in urine, perspiration, saliva, or tears (yellow, orange, red, or brown). This is a mild side effect that will fade gone once the drug is stopped. Teeth and contact lens staining, on the other hand, maybe persistent.

Rifampin can cause significant liver damage in rare cases. Combination treatment with other medications (e.g., isoniazid, pyrazinamide) may raise this risk, even if it is occasionally necessary to completely treat some illnesses. Due to a form of resistant bacteria, this medicine can occasionally cause a serious intestinal illness called Clostridium difficile-associated diarrhea. This condition can develop during medication or weeks or months after it has ended. If you have any of the typical medications, avoid taking anti-diarrhea or opioid drugs since they may aggravate them.

This medicine seldom causes a severe allergic reaction. However, if you detect any signs of significant allergic response, such as persistent fever, new or worsened lymph node enlargement, rashes, itching/swelling, severe dizziness, or problems breathing, seek medical attention right once.

Notify the doctor or pharmacist about your medical history, particularly if you have diabetes, liver issues (e.g., hepatitis), HIV infection, or a history of alcohol use or abuse. Rifampin may impair the effectiveness of live bacterial vaccinations (such as the typhoid vaccine). Unless your doctor advises otherwise, do not get any vaccines or vaccinations while taking this drug.

This drug should only be taken during pregnancy if necessary. The risk of bleeding in both the baby and the mother may be increased if this medicine is taken during the last few weeks of pregnancy. If anyone observes any bleeding in the infant, call the doctor right away. Contact the doctor or physician about the dangers and advantages. Rifampin is excreted in breast milk, however, it is unlikely to damage a nursing baby. Before you start breastfeeding, seek medical advice.

36 months is the shelf life of Rifampicin.

Sickness, vomiting, stomach pain, itching, headache, and increased tiredness will almost certainly occur shortly after acute consumption; sleepiness may occur if a severe liver illness is present. There may be a brief rise in liver function and/or bilirubin. Complexion, urine, sweating, saliva, emotions, and excrement will turn a brownish-red or orange color, with the intensity corresponding to the amount consumed. Pediatric patients have also been documented to have facial or periorbital edema. There were reports of hypotension, sinus tachycardia, ventricular rhythms, convulsions, and heart attack.

The individuals who have taken this medicine do not have any substantial or significant adverse effects. Rifampin can cause significant liver damage in rare cases. Combination treatment with other medications (e.g., isoniazid, pyrazinamide) may raise this risk, even if it is occasionally important to adequately treat some illnesses.

There is no instruction on how to modify the patient's body weight. However, the drug has a standard dose.