Quetiapine Fumarate
Quetiapine Fumarate is used to treat symptoms of schizophrenia, which affects the way we think,
feel and behave, Bipolar 1 disorder, which causes sustained mood swings, mania, or depression.
patients experience overactivity, elation, or irritability in manic episodes and in depression,
depression or guilty, fatigue, loss of appetite, and trouble sleeping. Quetiapine both treats and
prevent the recurrence of bipolar disorder.
Quetiapine Fumarate is sold under the brand names Qmax, Qpine, Quiet amongst others.
Ici Americas Inc. filed their first patents for Thiazepine compounds in 1986 in Europe which was
followed by Therics, Inc. filing for the patent in the USA in 2002. It was approved by FDA to treat
Schizophrenia in 1997, which was followed by approval to treat bipolar in 2003 and approved as an
adjunct in the treatment of major depressive disorder in 2009. The current patent assignee is Teva
Pharmaceuticals USA Inc since 2006.
Dosage and administration
Quetiapine Fumarate is sold as tablets. The dosage is decided for each patient by their doctor which
depends on the condition and other medicines already in use. Then the normal dose is usually once
or twice a day. The tablets are to be swallow whole with a full of water. They should be taken even
spaced, at the same time every day for best effect.
The price of Quetiapine Fumarate
In the USA, the consumer has to pay an average cost of USD 20 for a supply of 30 Tablets of 25mg
each of the generic brand. This medicine is much cheaper in the developing parts of the world. In
India, the price of 30 tablets of 50mg cost only around USD 0.45.
How does it work?
Quetiapine is a second-generation antipsychotic. It has an affinity for D2, 5-HT2A, H1, alpha 1, and 5-
HT1A receptors. Quetiapine’s precise mechanism is not yet full described, but dopamine theory of
schizophrenia suggests that the antipsychotic effects could be due to its ability to reduce
dopaminergic neurotransmission in the mesolimbic pathway. This helps to correct chemical
imbalances in the brain.
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