PYRIDOXINE HYDROCHLORIDE

Pyridoxine or vitamin B6 is used to prevent or treat low levels of vitamin B6 in population with dietary deficiency of B6. While normal diet should give the body enough B6, patient with conditions such as alcoholism, liver disease, overactive thyroid, heart failure or on medications like isoniazid, cycloserine, hydralazine, penicillamine see a drop in the B6 levels. Vitamin B6 is vital to the human body as it maintains the health of nerves, skin, and red blood cells.

As a supplement, Pyridoxine treats and preventds pyridoxine deficiency, sideroblastic anaemia, pyridoxine-dependent epilepsy, certain metabolic disorders. It also treats a rare type of epilepsy which cannot be treated other typical antiseizure medications. Pyridoxine with doxylamine treats morning sickness in pregnant women.

Pyridoxine is sold under the brand names Vitamin B6, Nestrex amongst others. However, this is a generic medicine and is sold OTC. It is made and sold by drug and food makers around the world. Merck and Dr Folkers first reported the structure in 1940. However, György and colleagues discovered Vitamin B6 (pyridoxine) in 1934, and Samuel Lepovsky first isolated the active compound in 1938.

Uses and dosage:

Pyridoxine is available as tablets, extended-release in 25 to 500mg strengths and as Capsule of 250mg. the recommended intake for Males younger than 50 years old is 1.3 mg per day 1.7 mg per day people over 50. for women younger than 50 years old is 1.3 mg per day 1.5 mg per day people over 50. For pregnant and lactating women, it is around 2mg per day. To treat for Pyridoxine Deficiency, the patient is prescribed10-20 mg per day for 3 weeks. For preventing nausea in Pregnancy, the women are given10-25 mg, every 8 hours and for preventing Peripheral Neuropathy, Patients are given isoniazid for Mycobacterium tuberculosis of 25-50 mg dose per day.

The price of Pyridoxine:

In India, the wholesale price for the ingredient version for 25 kilograms is around USD50. For the tablets, in the USA, the consumers have to pay the average retail price of $2.92 for 30 tablets of 25mg strength.

How does it work?

Pyridoxine from the vitamin B family of vitamins. The body makes amino acids, carbohydrates, and lipids using vitamin B6. It is also needed for muscle phosphorylase activity for glycogen metabolism. Pyridoxine converts tryptophan to niacin or serotonin and is involved in the breakdown of glycogen to glucose-1-phosphate. It also converts oxalate to glycine and synthesizes heme and gamma-aminobutyric acid within the CNS.

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