Dexchlorpheniramine Maleate

Dexchlorpheniramine Maleate is an antihistamine used to relieve symptoms of allergy, hay fever, and the common cold. These symptoms are rashes, watery eyes, itchy eyes or nose or throat or skin, cough, sneezing, and a runny nose. Dexchlorpheniramine Maleate is an antagonist of the histamine H1 receptor with anticholinergic properties and is a dextrorotatory isomer of chlorpheniramine. It is the S- the enantiomer of chlorpheniramine which is a 1st generation anti-histamine. Dexchlorpheniramine has a wider range of pharmacological uses than others and is far more potent than the racemic mixture. Dexchlorpheniramine treats seasonal and perennial allergic rhinitis, vasomotor rhinitis, allergic conjunctivitis due to inhalant allergens and foods, mild uncomplicated allergic skin manifestations of urticarial, dermographism, angioedema, amelioration of allergic reactions to plasma or blood. Dexchlorpheniramine Maleate is traded under the name Ryclora amongst others. Merck Sharp and Dohme Corp patented it first in 1962 and came into medical use in 1969.

Dosage and administration

Dexchlorpheniramine Maleate is available as an Oral Solution. It is sold as a red-colored, cherry-flavored liquid in 4 fl oz or 118 mL and 16 fl oz or 473 mL sizes. Dexchlorpheniramine Maleate dosage should be set as the needs of the patient. The recommended dose for Adults and Children 12 years of age and older is 2 mg or one teaspoonful, for Children between 6 to 11 years, the dose is set at 1 mg or half a teaspoonful and for children between 2 to 5 years, the dose is set at 0.5 mg or one-fourth of a teaspoonful. The general time interval between the doses is 4 to 6 hours.

The cost of DEXCHLORPHENIRAMINE MALEATE

In the USA, the consumer has to pay an average price of around $886.99 for 118ML of 2MG/5ML Bottle. This medicine is significantly cheaper in the developing and underdeveloped world. Consumers in India have to pay only around USD3.5 for 200 tablets.

How does DEXCHLORPHENIRAMINE MALEATE work?

Dexchlorpheniramine Maleate blocks histamine, made by the body during an allergic reaction. It also blocks Acetylcholine. This results in relieving the symptoms of allergy like watery eyes and runny nose. During a reaction, the allergen binds itself to the IgE antibodies on mast cells and basophils. The result of biding is that the IgE receptors crosslink with each other. This initiates events that eventually result in cell-degranulation and in the process, gets rid of the histamine inside the mast cell or basophil. Histamine reacts to both local and widespread tissues via its receptors. Histamine produces pruritis, vasodilatation, hypotension, headache, flushing, bronchoconstriction, and tachycardia. It improves vascular permeability and potentiates pain.

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