Protamines are amino group nuclear proteins that are hypothesized to be required for sperm head condensation and DNA integrity late in the haploid stage of spermatogenesis. They may enable more compact DNA packaging in the spermatozoon than histones, but the genetic data must first be decompressed before it can be used for protein synthesis. In humans and maybe other primates, however, histones bundle 10-15% of the sperm genome, which is thought to bind genes important for early embryonic development. The sperm-specific nuclear basic proteins are made up of protamine and protamine-like (PL) proteins (SNBPs). The PL proteins have a structure that is halfway between protamine and Histone H1. It's possible that the C-terminal region of PL is the precursor to vertebrate protamine.

Protamine is a rather strong basic protein that interacts with strongly acidic heparin to form a stable and inactive complex (salt) when used as an antidote to heparin, according to popular belief. The anticoagulant activity of both solitary protamine and heparin is neutralized by this inactive combination of protamine and heparin. Protamine is useful for treating bleeding caused by severe heparin or low-molecular-weight heparin overdose because it acts as an effective antidote to reverse the activity of heparin. Moreover, protamine is commonly used to counteract the effects of heparin prior to the surgery and during extracorporeal circulation therapies like hemodialysis or cardiac surgery.

An online search for the wholesale price for sale of Protamine for distributors will reveal a wide range of costs. It will vary from store to store depending on your visit and the country of the wholesale market.

Being a global B2B pharmaceutical online marketplace, Pipelinepharma is structured to simplify pharmaceutical deals by providing you with an intuitive interface that is easy to engage with. The selection of Protamine distributors offerings can be narrowed down with the use of filters and easily weighed against one another according to medication prices and commercial terms. The advanced filters help you filter out the countries for these substance manufacturers and this substance Protamine suppliers that you are looking for. These also enable you to check the dossier status of this medicine and the GMP approvals of the different variants of Protamine. Also, each manufacturer or supplier product description contains essential information about this substance including clinical data, stability zones, countries where Protamine is already registered in. Manufacturers also have special, and delivery terms.

If you are a pharmaceutical licensing company or a distributor you can enter into deals or negotiations over these medicine offers with manufacturing companies after completing the free registration process and joining our online marketplace. This helps to ensure that you conclude the pharmaceutical product deal at a reasonable cost and achieve the best cost/benefit ratio for your company while bypassing lengthy sourcing, negotiation, and order process. Once you have finalized a deal, you can look forward to a long-lasting business relationship with the manufacturers' Protamine suppliers. This way, the marketplace allows you as a distributor to skip the process of shortlisting product manufacturers every time you are looking for in-licensing or distribution deals.

To keep up to the quality standards other than Good Manufacturing Practice approvals that this medicine manufacturers list has, we qualify their companies before they are onboarded on the platform. This allows us to screen Protamine Manufacturers for the quality of the pharmaceutical products’ dossiers and protect against the risk of possible malpractices.