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1 products found

pp-098

Gel

Dossier type
CTD
Dossier status
Under development
Country of origin
Israel
Comments
Indication: Keratinization disorders including pachyonychia congenita and other hyperkeratosis‑related skin diseases in adults and pediatric populations as appropriate Clinical stage: Early clinical development — Phase 1b proof‑of‑concept completed / ongoing exploration with potential Phase 2 plans and feasibility studies Modality: Small molecule (tyrosine kinase inhibitor) in topical form Mechanism / Target: Inhibitor of epidermal growth factor receptor (EGFR), aiming to reduce epidermal hyperproliferation and abnormal keratinization Route / form: Topical gel formulation designed for direct skin application Differentiation: First topical erlotinib formulation optimized for higher local concentration with minimal systemic exposure, intended to address rare hyperkeratosis conditions that lack approved targeted therapies
Manufacturer #38928

Clinical-stage biotechnology company developing targeted topical therapies for rare dermatologic conditions. Focuses on hedgehog pathway inhibitors to prevent basal cell carcinoma lesions. Strategy emphasizes global clinical trials and future commercialization partnerships.

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