Pemetrexed is a chemotherapy medication used to treat malignant pleural mesothelioma and non-small cell lung cancer. When surgery is not an option, pemetrexed injection is frequently used in conjunction with another chemotherapeutic drug as a first line treatment for malignant pleural mesothelioma. The drug pemetrexed belongs to a group of drugs known as antifolate antineoplastic agents. Suppliers of pemetrexed market it as concentrates as well as lyophilized powders for intravenous infusion. The clinical developer and earliest manufacturer of pemetrexed is Eli Lilly, who first introduced the drug in 2004 under the trade name Alimta. Alimta was granted FDA approval for the treatment of tumors of the mesothelium in 2004, and the treatment of non-small lung cancer in 2008. The patent for pemetrexed expired in Europe and Japan in 2015 and in the U.S. in 2017. Although manufacturer Eli Lily managed to stave off market entry from competitors in the U.S. until 2020, other manufacturers of pemetrexed have introduced generic variants of the drug across other geographic markets. Such companies include Pfizer, Glenmark, STADA Arzneimittel, Teva, and Novartis. Also, pemetrexed and pembrolizumab, a drug marketed by major U.S. manufacturer Merck & Co. under the trade name Keytruda, are clinically proven to complement each other in oncological treatment. FDA has termed the drug combination as the first-line treatment of non-small lung cancer.
How Does Pemetrexed Work?
It functions by preventing a certain chemical from acting in the body in a way that might promote the growth of cancer cells. Pemetrexed, an antifolate with pyrrolopyrimidine-based nucleus, inhibits folate-dependent metabolic processes necessary for cell replication in order to exert its anticancer action. Pemetrexed suppresses all folate-dependent enzymes are involved in the de novo production of thymidine and purine nucleotides, including thymidylate synthase, dihydrofolate dehydrogenase, and glycinamide ribonucleotide formyltransferase, according to in vitro studies. Both the membrane folate interacting protein transport mechanism and the decreased folate carrier are used to deliver pemetrexed into cells. The molecule folylpolyglutamate synthetase transforms pemetrexed into polyglutamate forms once it has entered the cell. The polyglutamate forms, which inhibit TS and GARFT, are kept in cells. In tumour cells and, to a lesser extent, in normal tissues, polyglutamation is a time- and concentration-dependent process.
Wholesale Price of Pemetrexed
Pemetrexed is a costly drug. Retail prices per 500mg of Alimta intravenous powder fall into an approximate range of 1000 EUR to 1600 EUR. Explore the offers of Pemetrexed from vendors on our pharmaceutical marketplace or to look up more essential online information about Pemetrexed. The price of Pemetrexed is higher than that of such substitutes, owing largely to the more costly manufacturing process needed to produce it. Also, the costs of Pemetrexed vary depending on manufacturer and supplier pricing, whether it is a generic or trade name formulation, concentration of the active ingredient in the formulation. It is available or sale at every medical store. Pemetrexed suppliers, on the whole, are in favor of patient aid initiatives. Pemetrexed is available for sale from various Pemetrexed vendors at multiple costs.
From Where to Get Pemetrexed?
Pharmaceutical specialists are welcome to browse through offers of Pemetrexed capsules, injectable solutions, and oral solutions from suppliers in our B2B pharmaceutical marketplace, or else find more information about Pemetrexed online at the official Epilepsy Foundation website. Making use of Pipelinepharma's worldwide B2B online marketplace for medications and other pharmaceuticals is the ideal approach to locate and acquire access to Pemetrexed manufacturers and suppliers. Finding reliable suppliers and manufacturers of particular medications like Pemetrexed can typically be a time-consuming challenge, but with Pipelinepharma's straightforward search engine and network of tested partners, the entire process becomes much simpler. Utilizing our built-in search engine, all you have to do to begin going is start looking for potential Pemetrexed suppliers or manufacturers. You may also use filters to narrow down your search results and look for Pemetrexed from particular nations.
Navigating our Pharmaceutical Marketplace
Being a global B2B pharmaceutical online marketplace, Pipelinepharma is structured to simplify pharmaceutical deals by providing you with an intuitive interface that is easy to engage with. The selection of Pemetrexed offerings can be narrowed down with filters and easily weighed against one another according to medication prices and commercial terms. The advanced filters help you filter out the countries for this substance manufacturer and Pemetrexed suppliers that you are looking for. These also enable you to check the dossier status of this medicine and the GMP approvals of the different variants of Pemetrexed. Also, each manufacturer or supplier product description contains essential information about this substance, including clinical data, stability zones, and countries in which Pemetrexed is already registered. Manufacturers also have special delivery terms.
Establishing Commercial Ties
Suppose you are a pharmaceutical licensing company or a distributor. In that case, you can enter into deals or negotiations over these medicine offers with manufacturing companies after completing the free registration process and joining our online marketplace. This helps ensure that you conclude the pharmaceutical deal at a reasonable cost and achieve the best cost/benefit ratio for your company while bypassing lengthy sourcing, negotiation, and order process. Once you have finalized a deal, you can look forward to a long-lasting business relationship with the Pemetrexed suppliers. This way, the marketplace allows you as a distributor to skip the process of making a list of product manufacturers every time you are looking for in-licensing or distribution deals.
To keep up to the quality standards other than Good Manufacturing Practice approvals that this medicine manufacturers list has, we qualify their companies before they are boarded on the platform. This allows us to screen Pemetrexed manufacturers for the quality of the pharmaceutical products' dossiers and protect against the risk of possible malpractices.