Octreotide Manufacturers
Octreotide, a synthetic long-acting drug belongs to a class of medication called Octapeptides. Octreotide is a synthetic protein that is similar to somatostatin (hormone) in the body.
Octreotide is used to treat severe watery diarrhea and sudden reddening / flushing of the face and neck in patients with tumors such as carcinoid, pancreatic islet cell tumors and vasoactive intestinal peptide-secreting tumors which are found in intestine and pancreas.
This drug is also used to treat acromegaly that occurs when the body produces too much growth hormone and the hands, feet, head grow too large.
Manufacturers of Octreotide market this drug under the Brand name of Bynfezia, Mycapssa, Sandostatin, Sandostatin LAR. This medication is available in the form of Capsule (delayed-release) and Injection (solution). The Capsule is taken by mouth and Injection may be administered subcutaneously or intramuscularly. Capsule form is available in dosage strength of 20 mg / 1 and Injectables / Vials are available in 10 mg per 5 mL, 20 mg per 5 mL or 30 mg per 5 mL dosage strengths.
The initial recommended adult dose of Octreotide for Acromegaly is 50 mcg, intravenously or subcutaneously, three times a day with a maximum dose of 500 mcg three times a day. This medication must start with a low dose which help patients adapt to any adverse events.
Octreotide capsule should be taken with a glass of water on an empty stomach at least 1 hour before a meal or 2 hours after a meal with a recommended dosage of 40 mg twice daily. The maximum recommended dosage is 80 mg.
Octreotide Capsule are stored at refrigerated temperature 2 C – 8 C (36 F – 46 F) before first use. After first use, the opened carton may be stored at 20 C – 25 C (68 F – 77 F) for up to 1 month.
Octreotide Injectable are stored at refrigerated temperature 2 C – 8 C (36 F – 46 F). At room temperature 20 C – 30 C (68 F – 86 F) the injectable is stable for 14 days if protected from light.
Wholesale Price of Octreotide
In US region the wholesale price for 50 mcg/mL Octreotide injectable solution is around $ 71.73 for a supply of 25 milliliters with per unit cost available at as low as $ 2.87. The lowest available price for 100 mcg/mL Octreotide injectable solution is around $ 38.06 for a supply of 10 milliliters with per unit cost available at as low as approximately $ 3.81
Octreotide - Mechanism of Action
Octreotide is a long-acting drug with pharmacologic activities similar to the natural hormone somatostatin. Somatostatin is produced in the body by the hypothalamus. Like somatostatin, Octreotide suppresses luteinizing hormone response to gonadotropin-releasing hormone, decreases splanchnic blood flow and inhibits the release of secretin, motilin, gastrin, serotonin, and pancreatic polypeptide which ultimately helps in controlling the symptoms of flushing and diarrhea in carcinoid tumors. Octreotide is very stable and longer acting compared to somatostatin.
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